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Comment
. 2022 Jan 7;7(67):eabn9190.
doi: 10.1126/sciimmunol.abn9190. Epub 2022 Jan 7.

Executive CoAching unleashes Tc22 anti-tumor capacity

Ramon I Klein Geltink  1 , Asha Pillai  2
Affiliations
Comment

Executive CoAching unleashes Tc22 anti-tumor capacity

Ramon I Klein Geltink et al. Sci Immunol. .

Abstract

CoA-driven mitochondrial metabolism enhances the anti-tumor properties of IL-22–producing CD8+ T cells.

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  • Coenzyme A fuels T cell anti-tumor immunity.
    St Paul M, Saibil SD, Han S, Israni-Winger K, Lien SC, Laister RC, Sayad A, Penny S, Amaria RN, Haydu LE, Garcia-Batres CR, Kates M, Mulder DT, Robert-Tissot C, Gold MJ, Tran CW, Elford AR, Nguyen LT, Pugh TJ, Pinto DM, Wargo JA, Ohashi PS. St Paul M, et al. Cell Metab. 2021 Dec 7;33(12):2415-2427.e6. doi: 10.1016/j.cmet.2021.11.010. Cell Metab. 2021. PMID: 34879240