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Meta-Analysis
. 2022 Oct;159(1):56-64.
doi: 10.1002/ijgo.14087. Epub 2022 Jan 26.

Single-dose antibiotic therapy for urinary infections during pregnancy: A systematic review and meta-analysis of randomized clinical trials

Gabriel Schuch Schulz  1 , Felipe Schütz  1 , Felipe Valentim Jung Spielmann  1 , Lucas Uglione da Ros  1 , Júlia Stüker de Almeida  1 , José Geraldo Lopes Ramos  1   2   3
Affiliations
Meta-Analysis

Single-dose antibiotic therapy for urinary infections during pregnancy: A systematic review and meta-analysis of randomized clinical trials

Gabriel Schuch Schulz et al. Int J Gynaecol Obstet. 2022 Oct.

Abstract

Background: During pregnancy, urinary infections are an important cause of maternofetal morbidity and mortality and may lead to several complications.

Objective: To verify whether the use of antibiotic therapy in a single dose when compared with multiple doses in lower tract urinary infections during pregnancy is effective to obtain microbiologic cure.

Search strategy: Online databases were searched. Keywords used were "single-drug dose", "antibiotic", "fosfomycin", "amoxicillin", "trimethoprim", "pregnancy", and "urinary tract infection".

Selection criteria: Studies were included if they were randomized controlled trials, the population was pregnant woman, microbiologic cure was attained, and one of the treatment groups received single-dose antibiotic therapy.

Data collection and analysis: Preselected studies have been independently read by pairs, and data were extracted according to a predetermined sheet. The Cochrane tool was used for the risk of bias.

Main results: A total of 1063 women from nine studies were included. The primary outcome was the microbiologic cure attested by urine culture. When compared with the multiple-day use of antibiotics, the single-dose treatment has shown statistically similar results in reaching culture cure (odds ratio 1.02, 95% confidence interval 0.73-1.44).

Conclusion: The current study has shown that the use of single-dose treatment for lower tract urinary infections during pregnancy can be recommended, especially using fosfomycin.

Systematic review registration: This review has not been registered.

Keywords: antibiotic; bacteriuria; cystitis; infection; pregnancy; single dose.

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References

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