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. 2022 Jan 6;30(1):4-5.
doi: 10.1016/j.str.2021.12.007.

How CEP164 ciliopathy mutations impair ciliogenesis

Ciaran G Morrison  1
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How CEP164 ciliopathy mutations impair ciliogenesis

Ciaran G Morrison. Structure. .
Free article

Abstract

CEP164 recruits TTBK2 to the distal end of centrioles to allow primary cilium formation. In this issue of Structure, Rosa e Silva et al. (2022) present co-crystallized structures that show the molecular basis of this recruitment and define how ciliopathy mutations in CEP164 disrupt the CEP164-TTBK2 complex.

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