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. 2022 Mar;101(3):635-636.
doi: 10.1016/j.kint.2021.12.018. Epub 2022 Jan 4.

SARS-CoV-2 vaccination-associated collapsing glomerulopathy in a kidney transplant recipient

Julia Jefferis  1 , Andrew J Kassianos  2 , Anca Grivei  3 , Brian Doucet  1 , Helen Healy  2 , Leo Francis  4 , Saw Yu Mon  1 , George T John  5
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SARS-CoV-2 vaccination-associated collapsing glomerulopathy in a kidney transplant recipient

Julia Jefferis et al. Kidney Int. 2022 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Timeline of kidney function and sequential biopsy results in a kidney transplant recipient. (a) Timeline of renal function/creatinine (black circles) and cyclosporine (white circles) levels, with arrows indicating timing of first and second AstraZeneca vaccinations. The asterisk indicates initiation of 1 g methylprednisolone, second daily plasma exchange, and i.v. Ig for 2 weeks, continued 60 mg prednisolone/D. (b) Kidney biopsy 1 before treatment shows enlarged glomeruli with features of glomerulitis with endocapillary lymphocytes, some neutrophils, and capillary loop narrowing (periodic Schiff–methenamine [PASM], original magnification ×200). Bar = 100 μm. (c) In biopsy 1, enlarged podocytes with protein droplets in their cytoplasm were noted in 2 glomeruli (hematoxylin and eosin, original magnification ×200). Bar = 100 μm. (d,e) The second biopsy (biopsy 2) 2 weeks later revealed 2 glomeruli containing large podocytes with prominent protein globules and collapse of underlying capillary loops ([d] PASM, original magnification ×200; [e] periodic acid–Schiff, original magnification ×200). Bars = 100 μm. (f) Ki-67 immunohistochemistry shows reactivity in multiple cells in Bowman’s space, consistent with either visceral or parietal epithelial cells. Some of the cells contain cytoplasmic protein droplets. Bar = 100 μm. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.
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References

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