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Review
. 2022 Apr;80(5):762-778.
doi: 10.1111/his.14609. Epub 2022 Feb 20.

Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020)

W Glenn McCluggage  1 , Naveena Singh  2 , C Blake Gilks  3
Affiliations
Review

Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020)

W Glenn McCluggage et al. Histopathology. 2022 Apr.

Abstract

An updated World Health Organization (WHO) classification of female genital tumours was published in autumn 2020. We discuss the major new additions to and changes from the prior 2014 classification with a discussion of the reasons underlying these. A feature of the new classification is the greater emphasis on key molecular events with integration of morphological and molecular features. Most of the major changes from the prior classification pertain to uterine (corpus and cervix) and vulval tumours, but changes in all organs are covered.

Keywords: World Health Organization; cervix; endometrium; female genital tract; tubo-ovarian.

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References

    1. WHO Classification of Tumours Editorial Board ed. World Health Organization classification of tumours. 5th ed. Female genital tumours. Lyon: IARC Press, 2020.
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    1. Kurman RJ, Carcangiu ML, Herrington CS, Young RH eds. World Health Organization classification of tumours of female reproductive organs. Lyon: IARC Press, 2014.
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    1. Croce S, Hostein I, Longacre TA et al. Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms. Mod. Pathol. 2019; 32; 1008-1022.

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