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. 2022 Jan 7;20(1):11.
doi: 10.1186/s12957-021-02478-x.

Prognosis and survival analysis of patients with pancreatic cancer: retrospective experience of a single institution

Qi Li  1 , Zijian Feng  1 , Ruyi Miao  1 , Xun Liu  1 , Chenxi Liu  1 , Zhen Liu  2
Affiliations

Prognosis and survival analysis of patients with pancreatic cancer: retrospective experience of a single institution

Qi Li et al. World J Surg Oncol. .

Abstract

Background: The overall survival of patients with pancreatic cancer is extremely low. Despite multiple large-scale studies, identification of predictors of patient survival remains challenging. This study aimed to investigate the prognostic factors for pancreatic cancer.

Methods: The clinical data of 625 patients with pancreatic cancer treated at Shengjing Hospital of China Medical University from January 2013 to December 2017 were collected.

Results: Of 625 patients, 569 were followed from 1 to 75 months. The median overall survival was 9.3 months. The overall 1-, 3-, and 5-year survival rates were 37.8%, 15.1%, and 10.5%, respectively. Cox proportional hazards model indicated that baseline carbohydrate antigen 199 level, neutrophil-lymphocyte ratio, operative procedure, lymph node metastasis, number of distant organ metastasis, and postoperative adjuvant chemotherapy were independent prognostic factors of patients with pancreatic cancer. Baseline carbohydrate antigen 199 level, degree of weight loss, operative procedure, lymph node metastasis, number of distant organ metastasis, and postoperative adjuvant chemotherapy were independent prognostic factors of pancreatic head cancer subgroup. Baseline carbohydrate antigen 199 level, carcinoembryonic antigen level, total bilirubin level, neutrophil-lymphocyte ratio, peripancreatic invasion, number of distant organ metastasis, and postoperative adjuvant chemotherapy were independent prognostic factors of the pancreatic body/tail cancer subgroup.

Conclusions: Higher carbohydrate antigen 199 levels, neutrophil-lymphocyte ratio, lymph node metastasis and distant organ metastasis predict a poor prognosis in patients with pancreatic cancer. Early detection, early radical surgery and adjuvant chemotherapy are needed to improve prognosis for this deadly disease.

Keywords: Clinicopathological factor; Cox regression analysis; Pancreatic cancer; Prognosis; Therapy method.

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Conflict of interest statement

The authors have declared that no competing interest exists.

Figures

Fig. 1
Fig. 1
Overall survival of 625 patients with PC. The overall 1-, 3-, and 5-year survival rates of 625 patients with PC were 37.8%, 15.1%, and 10.5%, respectively. The mOS was 9.3 months (95% CI, 8.5–10.1).
Fig. 2
Fig. 2
Comparison of survival of patients with different clinical factors. A Comparison of survival of patients with different CA199 levels. Survival was significantly worse with increased CA199 levels (P<0.05). B Comparison of survival of patients with NLR <5 or NLR ≥5. Survival was significantly worse in patients with NLR ≥5 (P<0.05). C Comparison of survival of patients undergoing different operative procedures. Patients undergoing palliative operation did not have significantly different survival from patients who did not undergo surgery (P>0.05). Patients undergoing radical resection had significantly longer survival time than patients who did not undergo radical resection (P<0.05). D Comparison of survival in patients with or without lymph node metastasis. Survival was significantly worse in patients with lymph node metastasis (P<0.05). E Comparison of survival in patients with different numbers of distal organ metastasis. Survival was significantly worse with the increase in the number of distal organ metastasis (P<0.05). F Comparison of survival in patients with or without postoperative adjuvant chemotherapy. Survival was significantly worse in patients without postoperative adjuvant chemotherapy (P<0.05).
See this image and copyright information in PMC

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