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Case Reports
. 2022 Mar-Apr;97(2):231-235.
doi: 10.1016/j.abd.2020.09.016. Epub 2022 Jan 4.

Necrotic erythema nodosum reaction associated with histological alterations of Lucio's phenomenon

Larissa Daniele Machado Góes  1 , Patrícia Motta de Morais  2 , Paula Frassinetti Bessa Rebello  3 , Antônio Pedro Mendes Schettini  2
Affiliations
Case Reports

Necrotic erythema nodosum reaction associated with histological alterations of Lucio's phenomenon

Larissa Daniele Machado Góes et al. An Bras Dermatol. 2022 Mar-Apr.

Abstract

Patients with lepromatous or borderline leprosy may present two types of vasculonecrotic reactions: Lucio's phenomenon (LP) and necrotic erythema nodosum leprosum (nENL). These are serious conditions, which mostly lead to life-threatening infectious and thrombotic complications. The authors report the case of a patient with leprosy recurrence associated with an atypical type II reaction with LP characteristics on histopathology.

Keywords: Leprosy; Multibacillary leprosy; Mycobacterium infections; Mycobacterium leprae.

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Figures

Figure 1
Figure 1
Presence of papules, pustules and crusts on the upper limbs and trunk.
Figure 2
Figure 2
(A), Erythematous papules, pustules and crusts affecting the left upper limb. (B), Bullae with purulent content on the left plantar region.
Figure 3
Figure 3
(A), Necrosis of the epidermis and dense inflammatory infiltrate in the dermis are observed (Hematoxylin & eosin, ×10). (B), Neutrophilic infiltrate on the wall and around the vessels (Hematoxylin & eosin, ×40). (C), Vacuolated macrophages containing large amounts of intact and fragmented bacilli (Wade, ×40).
See this image and copyright information in PMC

References

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