Comment

. 2022 Nov;71(11):2369-2371.

doi: 10.1136/gutjnl-2021-326670. Epub 2022 Jan 7.

Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

Yuan-Chen Wang^{1

2}, Xiao-Tong Mao^{1

2}, Dong Yu³, Sheng-Han Mao^{1

2}, Zhao-Shen Li^{1

2}, Wen-Bin Zou^{4

2}, Zhuan Liao^{4

2}

Affiliations

¹ Department of Gastroenterology, Changhai Hospital, Shanghai, China.
² Shanghai Institute of Pancreatic Diseases, Shanghai, China.
³ Department of Precision Medicine, Translational Medicine Research Center, Second Military Medical University, Shanghai, China.
⁴ Department of Gastroenterology, Changhai Hospital, Shanghai, China liaozhuan@smmu.edu.cn dr.wenbinzou@hotmail.com.

PMID: 34996825
DOI: 10.1136/gutjnl-2021-326670

Comment

Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

Yuan-Chen Wang et al. Gut. 2022 Nov.

. 2022 Nov;71(11):2369-2371.

doi: 10.1136/gutjnl-2021-326670. Epub 2022 Jan 7.

Authors

Yuan-Chen Wang^{1

2}, Xiao-Tong Mao^{1

2}, Dong Yu³, Sheng-Han Mao^{1

2}, Zhao-Shen Li^{1

2}, Wen-Bin Zou^{4

2}, Zhuan Liao^{4

2}

Affiliations

¹ Department of Gastroenterology, Changhai Hospital, Shanghai, China.
² Shanghai Institute of Pancreatic Diseases, Shanghai, China.
³ Department of Precision Medicine, Translational Medicine Research Center, Second Military Medical University, Shanghai, China.
⁴ Department of Gastroenterology, Changhai Hospital, Shanghai, China liaozhuan@smmu.edu.cn dr.wenbinzou@hotmail.com.

PMID: 34996825
DOI: 10.1136/gutjnl-2021-326670

No abstract available

Keywords: chronic pancreatitis; genetic polymorphisms.

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Conflict of interest statement

Competing interests: None declared.

Comment in

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Modelling chronic pancreatitis as a complex genetic disease in mice.
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Comment on

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators. Derikx MH, et al. Gut. 2015 Sep;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Epub 2014 Sep 24. Gut. 2015. PMID: 25253127
Common variants at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with chronic pancreatitis in Japan.
Masamune A, Nakano E, Hamada S, Kakuta Y, Kume K, Shimosegawa T. Masamune A, et al. Gut. 2015 Aug;64(8):1345-6. doi: 10.1136/gutjnl-2015-309802. Epub 2015 May 22. Gut. 2015. PMID: 26002935 No abstract available.
Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639.
Boulling A, Sato M, Masson E, Génin E, Chen JM, Férec C. Boulling A, et al. Gut. 2015 Nov;64(11):1837-8. doi: 10.1136/gutjnl-2015-310254. Epub 2015 Aug 5. Gut. 2015. PMID: 26246244 No abstract available.
Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis.
Hegyi E, Tóth AZ, Vincze Á, Szentesi A, Hegyi P, Sahin-Tóth M. Hegyi E, et al. Gut. 2020 Sep;69(9):1713-1715. doi: 10.1136/gutjnl-2019-319729. Epub 2019 Sep 10. Gut. 2020. PMID: 31506327 Free PMC article. No abstract available.

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Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

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Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

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