Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

Yuan-Chen Wang^{1

2}, Xiao-Tong Mao^{1

2}, Dong Yu³, Sheng-Han Mao^{1

2}, Zhao-Shen Li^{1

2}, Wen-Bin Zou^{4

2}, Zhuan Liao^{4

2}

Affiliations

¹ Department of Gastroenterology, Changhai Hospital, Shanghai, China.
² Shanghai Institute of Pancreatic Diseases, Shanghai, China.
³ Department of Precision Medicine, Translational Medicine Research Center, Second Military Medical University, Shanghai, China.
⁴ Department of Gastroenterology, Changhai Hospital, Shanghai, China liaozhuan@smmu.edu.cn dr.wenbinzou@hotmail.com.

PMID: 34996825
DOI: 10.1136/gutjnl-2021-326670

Comment

Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

Yuan-Chen Wang et al. Gut. 2022 Nov.

. 2022 Nov;71(11):2369-2371.

doi: 10.1136/gutjnl-2021-326670. Epub 2022 Jan 7.

Authors

Yuan-Chen Wang^{1

2}, Xiao-Tong Mao^{1

2}, Dong Yu³, Sheng-Han Mao^{1

2}, Zhao-Shen Li^{1

2}, Wen-Bin Zou^{4

2}, Zhuan Liao^{4

2}

Affiliations

¹ Department of Gastroenterology, Changhai Hospital, Shanghai, China.
² Shanghai Institute of Pancreatic Diseases, Shanghai, China.
³ Department of Precision Medicine, Translational Medicine Research Center, Second Military Medical University, Shanghai, China.
⁴ Department of Gastroenterology, Changhai Hospital, Shanghai, China liaozhuan@smmu.edu.cn dr.wenbinzou@hotmail.com.

PMID: 34996825
DOI: 10.1136/gutjnl-2021-326670

No abstract available

Keywords: chronic pancreatitis; genetic polymorphisms.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Comment in

Alcohol predisposes obese mice to acute pancreatitis via adipose triglyceride lipase-dependent visceral adipocyte lipolysis.
Yang X, Yao L, Dai L, Yuan M, He W, Liu T, Fu X, Xue J, Sutton R, Xia Q, Huang W. Yang X, et al. Gut. 2023 Jan;72(1):212-214. doi: 10.1136/gutjnl-2022-326958. Epub 2022 Apr 22. Gut. 2023. PMID: 35459708 Free PMC article. No abstract available.
Modelling chronic pancreatitis as a complex genetic disease in mice.
Jancsó Z, Demcsák A, Sahin-Tóth M. Jancsó Z, et al. Gut. 2023 Feb;72(2):409-410. doi: 10.1136/gutjnl-2022-327601. Epub 2022 May 16. Gut. 2023. PMID: 35577534 Free PMC article. No abstract available.

Comment on

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators. Derikx MH, et al. Gut. 2015 Sep;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Epub 2014 Sep 24. Gut. 2015. PMID: 25253127
Common variants at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with chronic pancreatitis in Japan.
Masamune A, Nakano E, Hamada S, Kakuta Y, Kume K, Shimosegawa T. Masamune A, et al. Gut. 2015 Aug;64(8):1345-6. doi: 10.1136/gutjnl-2015-309802. Epub 2015 May 22. Gut. 2015. PMID: 26002935 No abstract available.
Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639.
Boulling A, Sato M, Masson E, Génin E, Chen JM, Férec C. Boulling A, et al. Gut. 2015 Nov;64(11):1837-8. doi: 10.1136/gutjnl-2015-310254. Epub 2015 Aug 5. Gut. 2015. PMID: 26246244 No abstract available.
Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis.
Hegyi E, Tóth AZ, Vincze Á, Szentesi A, Hegyi P, Sahin-Tóth M. Hegyi E, et al. Gut. 2020 Sep;69(9):1713-1715. doi: 10.1136/gutjnl-2019-319729. Epub 2019 Sep 10. Gut. 2020. PMID: 31506327 Free PMC article. No abstract available.

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Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

Affiliations

Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

Authors

Affiliations

Conflict of interest statement

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