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Review
. 2022 Jan;149(1):24-28.
doi: 10.1016/j.jaci.2021.11.016.

Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

Aristine Cheng  1 , Steven M Holland  2
Affiliations
Review

Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

Aristine Cheng et al. J Allergy Clin Immunol. 2022 Jan.

Abstract

Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.

Keywords: Anticytokine autoantibodies; adult-onset immunodeficiency; anti-IFN-alpha; anti–CM-CSF; anti–IFN-γ; anti–IL-12; anti–IL-17; anti–IL-23; chronic mucocutaneous candidiasis; opportunistic infections; protein alveolar proteinosis.

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Conflict of interest statement

Disclosures:

Neither authors have potential conflicts of interest to declare.

Figures

Figure 1:
Figure 1:
Pictorial abstract of the disease associations and mechanistic-based therapy of anti-cytokine autoantibodies.
See this image and copyright information in PMC

References

    1. Browne SK. Anticytokine autoantibody-associated immunodeficiency. Annu Rev Immunol 2014;32:635–57. - PubMed
    1. Barcenas-Morales G, Cortes-Acevedo P, Doffinger R. Anticytokine autoantibodies leading to infection: early recognition, diagnosis and treatment options. Curr Opin Infect Dis 2019;32(4):330–6. - PMC - PubMed
    1. Ku CL, Chi CY, von Bernuth H, Doffinger R. Autoantibodies against cytokines: phenocopies of primary immunodeficiencies? Hum Genet 2020;139(6–7):783–94. - PMC - PubMed
    1. Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, et al. Adult-onset immunodeficiency in Thailand and Taiwan. N Engl J Med 2012;367(8):725–34. - PMC - PubMed
    1. Puel A, Döffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C, et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med 2010;207(2):291–7. - PMC - PubMed

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