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. 1987 Sep;31(9):1426-8.
doi: 10.1128/AAC.31.9.1426.

Role of beta-lactamase in expression of resistance by methicillin-resistant Staphylococcus aureus

J M Boyce  1 , A A Medeiros
Affiliations

Role of beta-lactamase in expression of resistance by methicillin-resistant Staphylococcus aureus

J M Boyce et al. Antimicrob Agents Chemother. 1987 Sep.

Abstract

Of 27 unique clinical isolates of methicillin-resistant Staphylococcus aureus, only 4 were homogeneously resistant, and all 4 produced little or no beta-lactamase. Among heterogeneously resistant strains, those most resistant to beta-lactam antibiotics produced the most beta-lactamase. Similar genes may regulate production of the low-affinity penicillin-binding protein and beta-lactamase.

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