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Review
. 2023 May;53(5):738-744.
doi: 10.1111/imj.15691. Epub 2022 Aug 31.

Neurosyphilis in the Northern Territory of Australia: a clinical guideline

Johanna Marie Birrell  1 , Michael Lowe  2 , Manoji Gunathilake  1 , Vicki Lynn Krause  1
Affiliations
Review

Neurosyphilis in the Northern Territory of Australia: a clinical guideline

Johanna Marie Birrell et al. Intern Med J. 2023 May.

Abstract

Background: The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT.

Aims: To explore the local epidemiologic, diagnostic and treatment complexities of neurosyphilis in the NT and produce a guideline for clinical practice.

Methods: A database search was undertaken and local and global neurosyphilis guidelines were analysed. A guideline was created based on findings of the critical review and consultation with local multidisciplinary experts.

Results: Neurosyphilis is frequently encountered in the NT but studies suggest it is often undertreated. Dementia is the most common clinical presentation locally. Establishing a diagnosis of neurosyphilis is complex and requires stepwise evaluation of clinical, laboratory and radiological findings.

Conclusions: A clinical guideline and algorithm have been developed for the diagnosis and management of patients with neurosyphilis.

Keywords: neurology; neurosyphilis; syphilis.

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References

    1. Hackett CJ. Boomerang leg and yaws in Australian Aborigines. Trans R Soc Trop Med Hyg 1936; 30: 137-43.
    1. Garner MF, Backhouse JL, Moodie PM, Tibbs GJ. Treponemal infection in the Australian Northern Territory aborigines. Bull World Health Organ 1972; 46: 285-93.
    1. Ward JS, Guy RJ, Akre SP, Middleton MG, Giele CM, Su JY et al. Epidemiology of syphilis in Australia: moving toward elimination of infectious syphilis from remote aboriginal and Torres Strait islander communities? Med J Aust 2011; 194: 525-9.
    1. Department of Health Multijurisdictional Syphilis Outbreak Surveillance Report: December 2019 [Cited July 2021]. Available from URL: https://www.health.gov.au/internet/main/publishing.nsf/Content/ohp-infec...
    1. Sexual Health & Blood Borne Virus Unit (SHBBVU). Surveillance Update - for Notifiable Sexually Transmitted Infections and Blood-Borne Viruses in the Northern Territory - January to March 2018; 19: 9-11.