Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Sep;6(9):2693-8.
doi: 10.1002/j.1460-2075.1987.tb02561.x.

Human CSF-1: gene structure and alternative splicing of mRNA precursors

M B Ladner  1 , G A Martin, J A Noble, D M Nikoloff, R Tal, E S Kawasaki, T J White
Affiliations

Human CSF-1: gene structure and alternative splicing of mRNA precursors

M B Ladner et al. EMBO J. 1987 Sep.

Abstract

Bone marrow progenitor cells differentiate into mononuclear phagocytes in the presence of colony stimulating factor-1 (CSF-1). Characterization of the human CSF-1 gene shows that it contains 10 exons and 9 introns, which span 20 kb. Analysis of multiple CSF-1 transcripts demonstrates that alternate use of exon 6 splice acceptor sites and 3' noncoding sequence exons occurs. These alternatively spliced transcripts can encode either a 224 or a 522 amino acid CSF-1. Implications of differential splicing for the production and function of CSF-1 are discussed.

PubMed Disclaimer

References

    1. Biochemistry. 1977 Oct 18;16(21):4743-51 - PubMed
    1. Biochem Biophys Res Commun. 1986 Dec 30;141(3):924-30 - PubMed
    1. Cell. 1978 Oct;15(2):687-701 - PubMed
    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. Blood. 1981 Sep;58(3):630-41 - PubMed

Associated data