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Review
. 2022 Feb;387(2):177-205.
doi: 10.1007/s00441-021-03551-3. Epub 2022 Jan 10.

Stem cell transplantation as a progressing treatment for retinitis pigmentosa

Sedighe Hosseini Shabanan  1 , Homa Seyedmirzaei  1   2   3 , Alona Barnea  4 , Sara Hanaei  1   2   3 , Nima Rezaei  5   6   7
Affiliations
Review

Stem cell transplantation as a progressing treatment for retinitis pigmentosa

Sedighe Hosseini Shabanan et al. Cell Tissue Res. 2022 Feb.

Abstract

Retinal degenerative diseases such as retinitis pigmentosa (RP) are of the major causes of vision loss in developed countries. Despite the unclear pathophysiology, treatment methods have been investigated vastly in the past decades. This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, neural stem cells, retinal progenitor cells, and olfactory ensheathing cells are discussed separately in addition to a brief description of two approaches for treatment of early-stage RP, including gene therapy and nutritional therapy.

Keywords: Cell therapy; Gene therapy; Nutritional therapy; Retinitis pigmentosa; Stem cell transplantation.

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