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. 2022 Jan;172(3):324-327.
doi: 10.1007/s10517-022-05385-7. Epub 2022 Jan 10.

Anti-Allergic Properties of Humic Acids Isolated from Pine-Sphagnum-Cotton Sedge Peat

E S Trofimova  1 , M V Zykova  2 , A A Ligacheva  3 , M G Danilets  3 , E Yu Sherstoboev  3 , L A Logvinova  2 , M V Belousov  2
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Anti-Allergic Properties of Humic Acids Isolated from Pine-Sphagnum-Cotton Sedge Peat

E S Trofimova et al. Bull Exp Biol Med. 2022 Jan.

Abstract

The course administration of humic acids isolated by the sodium pyrophosphate method from pine-sphagnum-cotton sedge peat reduced the general anaphylaxis reaction in mice and guinea pigs immunized with ovalbumin and decreased serum content of IgG1 and IgE in mice. The serum from mice treated with humic acids and sensitized with ovalbumin did not increase the rate of degranulation of mast cells isolated from intact Wistar rats in the presence of ovalbumin in comparison with the serum of control animals.

Keywords: anaphylaxis; humic acids; mast cell degranulation; ovalbumin.

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