Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar;14(3):167-178.
doi: 10.1111/1753-0407.13248. Epub 2022 Jan 10.

Relationship between creatinine to body weight ratios and diabetes mellitus: A Chinese cohort study

Zhuangsen Chen  1   2 , Yang Zou  3   4 , Fan Yang  5   6 , Xiao Han Ding  5   6 , Changchun Cao  7 , Haofei Hu  6   8 , Xinyu Wang  5   6
Affiliations

Relationship between creatinine to body weight ratios and diabetes mellitus: A Chinese cohort study

Zhuangsen Chen et al. J Diabetes. 2022 Mar.

Abstract
in English, Chinese

Background: Research on the relationship between creatinine to body weight ratios (Cre/BW ratios) and the prevalence of diabetes is still lacking. The intention of this research was to explore the potential relationship between Cre/BW ratio and diabetes prevalence in Chinese adults.

Methods: This retrospective study was conducted on 199 526 patients in the Chinese Rich Healthcare Group from 2010 to 2016. The participants were divided into four groups on the basis of the quartiles of the Cre/BW ratios. Multivariate multiple imputation and dummy variables were used to handle missing values. Multivariate regression analysis was applied to detect the relationship between Cre/BW and diabetes. A smoothing plot was also used to identify whether there were nonlinear relationships.

Results: After handling missing values and adjusting for potential confounders, the multivariate Cox regression analysis results showed that Cre/BW was inversely correlated with diabetes risk (hazard ratio [HR]: 0.268; 95% confidence interval [CI]: 0.229-0.314, p < 0.00001). For men, the HR of incident diabetes was 0.255 (95% CI: 0.212-0.307) and for women it was 0.297 (95% CI: 0.218-0.406). Moreover, sensitivity analysis confirmed the stability of the results. Furthermore, the smoothing plot revealed that there was a saturation effect between Cre/BW and the incidence of diabetes.

Conclusions: This study demonstrated that increased Cre/BW is negatively correlated with diabetes in Chinese adults. It also found that Cre/BW has a nonlinear relationship with the incidence of diabetes.

背景: 肌酐/体重比值(Cre/BW)与糖尿病患病率的关系尚缺乏研究。本研究旨在探讨CRE/BW比值与中国成年人糖尿病患病率之间的潜在关系。 方法: 本回顾性队列研究纳入中国华富医疗项目(Chinese Rich Healthcare Group)从2010 -2016年的199,526例患者。根据Cre/BW比率的四分位数，参与者被分成四组。应用多重插补及哑变量处理缺失值。采用多元回归分析探讨Cre/BW与糖尿病发病风险之间的关系，并运用平滑拟合曲线分析两者是否存在非线性关系。 结果: 在所有受试者中，在处理缺失值和校正潜在混杂因素后，多元回归分析结果显示，Cre/BW与糖尿病风险呈负相关(HR:0.268；95%CI:0.229~0.314，P<0.00001)；男性发生糖尿病的危险比(HR)为0.255(95%CI:0.212~0.307)；女性为0.297(95%CI:0.218~0.406)，敏感性分析证实了结果的稳定性。此外，平滑拟合曲线分析显示CRE/BW与糖尿病发病率之间存在饱和效应。 结论: 本研究表明中国人Cre/BW增加与糖尿病呈负相关。研究还发现，Cre/BW与糖尿病发病率之间存在非线性关系。.

Keywords: body weight; creatinine; diabetes incident; dummy variables; multiple imputations; nonlinearity; 体重; 哑变量; 多重插补; 糖尿病发病率; 肌酐; 非线性。.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
The nonlinear relationship between Cre/BW and incidence of diabetes (A), and a nonlinear relationship between them in different sexes (B). Abbreviation: Cre/BW, creatinine to body weight ratio
FIGURE 2
FIGURE 2
Kaplan–Meier event‐free survival curve. (A) Kaplan–Meier analysis of incidence of diabetes based on Cre/BW quartiles (log‐rank, p < 0.0001) in total. (B) Kaplan–Meier analysis of the incidence of diabetes in men. (C) Kaplan–Meier analysis of the incidence of diabetes in women. Abbreviation: Cre/BW, creatinine to body weight ratio
FIGURE 3
FIGURE 3
The results of receiver operating characteristics curves. Abbreviations: BMI, body mass index; Cre/BW, creatinine to body weight ratio; HDL‐C, high‐density lipoprotein cholesterol; TG, triglyceride
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. International Diabetes Federation . IDF Diabetes Atlas. 9th ed. Brussels: International Diabetes Federation; 2019.
    1. Sinclair A, Saeedi P, Kaundal A, Karuranga S, Malanda B, Williams R. Diabetes and global ageing among 65–99‐year‐old adults: findings from the international diabetes federation diabetes atlas. Diabetes Res Clin Pract. 2020;162:108078. - PubMed
    1. Williams R, Karuranga S, Malanda B, et al. Global and regional estimates and projections of diabetes‐related health expenditure: results from the international diabetes federation diabetes atlas. Diabetes Res Clin Pract. 2020;162:108072. - PubMed
    1. Ye Q, Fu JF. Paediatric type 2 diabetes in China‐pandemic, progression, and potential solutions. Pediatr Diabetes. 2018;19:27‐35. - PubMed
    1. Zierath JR, Krook A, Wallberg‐Henriksson H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia. 2000;43:821‐835. - PubMed