Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Jan-Dec:10:23247096211055334.
doi: 10.1177/23247096211055334.

A 66-Year-Old Man With Subacute Cough and Worsening Dyspnea Previously Diagnosed With COVID-19 Pneumonia

Affiliations
Case Reports

A 66-Year-Old Man With Subacute Cough and Worsening Dyspnea Previously Diagnosed With COVID-19 Pneumonia

Michelle A Quan et al. J Investig Med High Impact Case Rep. 2022 Jan-Dec.

Abstract

A 66-year-old man presented with subacute cough and worsening dyspnea. Labs were notable for moderate peripheral eosinophilia, and computed tomography (CT) scan demonstrated extensive crazy-paving throughout bilateral upper lung fields. Bronchoalveolar lavage (BAL) revealed macrophages with lipid-filled vacuoles and negative periodic acid-Schiff (PAS) stain. Further history obtained from the patient and family was notable for daily application of commercially available vapor rub to nares and intentional deep inhalation of nebulized fluids containing scented oils. The patient was diagnosed with exogenous lipoid pneumonia through an unusual route of lipid administration.

Keywords: COVID-19; lipoid pneumonia; pulmonary critical care.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
CT chest findings of crazy-paving pattern throughout all lung fields. Abbreviation: CT, computed tomography.
Figure 2.
Figure 2.
Lipid-laden alveolar macrophages.
Figure 3.
Figure 3.
Positive Oil Red O staining.

Similar articles

References

    1. Laughlen GF. Studies on pneumonia following naso-pharyngeal injections of oil. Am J Pathol. 1925;1(4):407-414. - PMC - PubMed
    1. Betancourt SL, Martinez-Jimenez S, Rossi SE, Truong MT, Carrillo J, Erasmus JJ. Lipoid pneumonia: spectrum of clinical and radiologic manifestations. Am J Roentgenol. 2010;194(1): 103-109. doi:10.2214/AJR.09.3040. - DOI - PubMed
    1. Spickard A, III, Hirschmann JV. Exogenous lipoid pneumonia. Arch Intern Med. 1994;154(6):686-692. doi:10.1001/archinte.1994.00420060122013. - DOI - PubMed
    1. Hadda V, Khilnani GC. Lipoid pneumonia: an overview. Expert Rev Respir Med. 2010;4(6):799-807. doi:10.1586/ers.10.74. - DOI - PubMed
    1. Hussain IR, Edenborough FP, Wilson RS, Stableforth DE. Severe lipoid pneumonia following attempted suicide by mineral oil immersion. Thorax. 1996;51(6):652-653; discussion 656-657. doi:10.1136/thx.51.6.652. - DOI - PMC - PubMed

Publication types