Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep-Oct;24(5):740-744.
doi: 10.4103/aian.AIAN_170_21. Epub 2021 Jun 22.

Coexistence of Autoantibodies and Other Autoimmune Diseases with Multiple Sclerosis and Related Disorders - Experience from the Mangalore Demyelinating Disease Registry (MANDDIR)

Chaithra Malli  1 , Lekha Pandit  1 , Mary A D'Çunha  1 , Akshatha Sudhir  1
Affiliations

Coexistence of Autoantibodies and Other Autoimmune Diseases with Multiple Sclerosis and Related Disorders - Experience from the Mangalore Demyelinating Disease Registry (MANDDIR)

Chaithra Malli et al. Ann Indian Acad Neurol. 2021 Sep-Oct.

Abstract

Background: Co-occurrence of other autoimmune disorders (AID) and autoantibodies in patients with autoimmune demyelinating CNS disorders have not been studied previously in patients of Indian origin.

Objective: To determine the frequency of concomitant autoimmune disorders, anti-nuclear antibody (ANA) and antithyroid antibody (ATAb) and to evaluate the impact on clinical course of disease.

Materials and methods: A total of 111 patients with MS and 152 patients with non-MS demyelinating disorders were included. Demographics, clinical course and disability were recorded. History of other autoimmune disorders (AIDs) in patients and first degree relatives was noted. Serum ANA and ATAb were tested.

Results: Concomitant AIDs were seen in 21% of MS and 19% of non-MS patients. Autoimmune thyroid disease was most frequent and seen in 10.8% of MS and 6.6% of non-MS disorders. Frequency of ATAb was significantly higher among MS group (MS 25.5% vs non-MS 13.2% P = 0.04) but that of ANA was similar between the 2 groups (MS 19.8% vs non-MS 26.9% P = 0.17). A positive family history of autoimmune disorders was noted in 20% of MS and 15.1% of non-MS disorders. Clinical course was unaffected by presence of concomitant AID and autoantibodies.

Conclusion: Cooccurrence of autoantibodies and AID are seen in a significant number of patients with MS and non-MS disorders and influences clinical management.

Keywords: Autoantibodies; autoimmune disorders; multiple sclerosis; non-MS disorders.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Autoantibodies and other autoimmune disorders in MS and related disorders
See this image and copyright information in PMC

References

    1. Sloka S. Observations on recent studies showing increased co-occurrence of autoimmune diseases. J Autoimmun. 2002;18:251–7. - PubMed
    1. Sloka JS, Phillips PW, Stefanelli M, Joyce C. Co-occurrence of autoimmune thyroid disease in a multiple sclerosis cohort. J Autoimmune Dis. 2005;9:2–9. - PMC - PubMed
    1. Munteisa E, Canob JF, Flores JA, Martinez-Rodrigueza JE, Miretb M, Roquera J. Prevalence of autoimmune thyroid disorders in a Spanish multiple sclerosis cohort. Eur J Neurol. 2007;14:1048–52. - PubMed
    1. Marie RN, Reider N, Cohen J, Stuve O, Sorensen PS, Cutter G, et al. A systematic review of the incidence and prevalence of autoimmune diseases in multiple sclerosis. Mult Scler J. 2015;21:282–93. - PMC - PubMed
    1. Long Y, Zheng Y, Chen M, Zhang B, Gao C, Shan F, et al. Serum thyroid-stimulating hormone and anti-thyroglobulin antibody are independently associated with lesions in spinal cord in central nervous system demyelinating diseases. PLoS One. 2014;9:e100672. - PMC - PubMed