Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022;27(1):38-44.
doi: 10.5863/1551-6776-27.1.38. Epub 2021 Dec 22.

Inhaled Budesonide in Neonatal Respiratory Distress Syndrome of Near-Term Neonates: A Randomized, Placebo-Controlled Trial

Mohamed S Elfarargy  1 , Ghada M Al-Ashmawy  2 , Sally M Abu-Risha  3 , Haidy A Khattab  4
Affiliations

Inhaled Budesonide in Neonatal Respiratory Distress Syndrome of Near-Term Neonates: A Randomized, Placebo-Controlled Trial

Mohamed S Elfarargy et al. J Pediatr Pharmacol Ther. 2022.

Abstract

Objective: This study evaluates the value of inhaled budesonide (BUD) administration in neonatal respiratory distress syndrome (RDS) cases especially for near-term neonates.

Methods: A randomized controlled trial involving 120 neonates with respiratory distress, which was diagnosed as RDS, was conducted from July 2016 to March 2018. The neonates studied were divided into 2 groups: group 1 (the inhaled BUD group), consisting of 60 neonates who received BUD (2 mL, 0.25-mg/mL suspension) inhalation, twice daily for 5 days; and group 2 (the placebo group), consisting of 60 neonates with RDS who received humidified distilled sterile water inhalation (2 mL). Downes score, RDS grades, and interleukin 8 (IL-8) levels were monitored and measured on the first and fifth days of incubation.

Results: Statistically significant differences (SSDs) in RDS grades, Downes score, and IL-8 levels on the fifth day of admission were observed between groups 1 and 2 (p = 0.001) and between the first and fifth days of incubation in group 1 (p = 0.001). The SSDs in the duration of hospitalization (p = 0.001) and the number of neonates receiving mechanical ventilation (p = 0.032) were found between both groups.

Conclusions: Budesonide inhalation is associated with improvements in clinical and laboratory parameters in neonates with RDS.

Keywords: budesonide; inhaled; neonate; respiratory distress; therapeutic.

PubMed Disclaimer

Figures

Figure.
Figure.
Consort or study flow chart of participating neonates in the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ye W, Zhang T, Shu Y et al. The influence factors of neonatal respiratory distress syndrome in Southern China: a case-control study. J Matern Fetal Neonatal Med . 2020;33(10):1678–1682. - PubMed
    1. Kothe TB, Sadiq FH, Burleyson N et al. Surfactant and budesonide for respiratory distress syndrome: an observational study. Pediatr Res . 2020;87(5):940–945. - PubMed
    1. De Bernardo G, De Santis R, Giordano M et al. Predict respiratory distress syndrome by umbilical cord blood gas analysis in newborns with reassuring Apgar score. Ital J Pediatr . 2020;46(1):20. - PMC - PubMed
    1. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Investig . 2012;122(8):2731–2740. - PMC - PubMed
    1. Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev . 2017;3:CD004454. - PMC - PubMed

LinkOut - more resources