Global Perspectives on Immunization Against SARS-CoV-2 During Pregnancy and Priorities for Future Research: An International Consensus Paper From the World Association of Infectious Diseases and Immunological Disorders

Bahaa Abu-Raya¹, Shabir A Madhi^{2

3}, Saad B Omer^{4

5}, Gayatri Amirthalingam⁶, Michelle L Giles^{7

8}, Katie L Flanagan^{9

10

11

12}, Petra Zimmermann^{13

14}, Miguel O'Ryan¹⁵, Marco A Safadi¹⁶, Vassiliki Papaevangelou¹⁷, Kirsten Maertens¹⁸, Nasamon Wanlapakorn¹⁹, Vicens Diaz-Brito²⁰, Eline Tommelein²¹, Susanna Esposito²²

Affiliations

¹ Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
² South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
³ African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁴ Department of Internal Medicine (Infectious Diseases), Yale School of Medicine, New Haven, CT, United States.
⁵ Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States.
⁶ Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, United Kingdom.
⁷ Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia.
⁸ Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
⁹ School of Medicine, Faculty of Health Sciences, University of Tasmania, Launceston, TAS, Australia.
¹⁰ School of Health and Biomedical Science, Royal Melbourne Institute of Technology (RMIT) University, Melbourne, VIC, Australia.
¹¹ Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia.
¹² Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS, Australia.
¹³ Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
¹⁴ Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland.
¹⁵ Microbiology and Mycology Program, Institute of Biomedical Sciences and Millennium Institute of Immunology and Immunotherapy, Faculty of Medicine, University of Chile, Santiago de Chile, Chile.
¹⁶ Department of Pediatrics, Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.
¹⁷ National and Kapodistrian University of Athens, Third Department of Pediatrics, University Hospital Attikon, Athens, Greece.
¹⁸ Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
¹⁹ Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
²⁰ Department of Infectious Diseases, Parc Sanitari Sant Joan de Déu,, Barcelona, Spain.
²¹ Department of Pharmacy, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
²² Pediatric Clinic, Pietro Barilla Children's Hospital, Department of Medicine and Surgery, University of Parma, Parma, Italy.

PMID: 35003137
PMCID: PMC8733958
DOI: 10.3389/fimmu.2021.808064

Review

Global Perspectives on Immunization Against SARS-CoV-2 During Pregnancy and Priorities for Future Research: An International Consensus Paper From the World Association of Infectious Diseases and Immunological Disorders

Bahaa Abu-Raya et al. Front Immunol. 2021.

. 2021 Dec 23:12:808064.

doi: 10.3389/fimmu.2021.808064. eCollection 2021.

Authors

Affiliations

¹ Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
² South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
³ African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁴ Department of Internal Medicine (Infectious Diseases), Yale School of Medicine, New Haven, CT, United States.
⁵ Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States.
⁶ Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, United Kingdom.
⁷ Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia.
⁸ Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
⁹ School of Medicine, Faculty of Health Sciences, University of Tasmania, Launceston, TAS, Australia.
¹⁰ School of Health and Biomedical Science, Royal Melbourne Institute of Technology (RMIT) University, Melbourne, VIC, Australia.
¹¹ Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia.
¹² Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS, Australia.
¹³ Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
¹⁴ Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland.
¹⁵ Microbiology and Mycology Program, Institute of Biomedical Sciences and Millennium Institute of Immunology and Immunotherapy, Faculty of Medicine, University of Chile, Santiago de Chile, Chile.
¹⁶ Department of Pediatrics, Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.
¹⁷ National and Kapodistrian University of Athens, Third Department of Pediatrics, University Hospital Attikon, Athens, Greece.
¹⁸ Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
¹⁹ Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
²⁰ Department of Infectious Diseases, Parc Sanitari Sant Joan de Déu,, Barcelona, Spain.
²¹ Department of Pharmacy, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
²² Pediatric Clinic, Pietro Barilla Children's Hospital, Department of Medicine and Surgery, University of Parma, Parma, Italy.

PMID: 35003137
PMCID: PMC8733958
DOI: 10.3389/fimmu.2021.808064

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with a higher risk for severe morbidity and mortality when compared with infection in non-pregnant women of childbearing age. An increasing number of countries recommend immunization against SARS-CoV-2 in pregnant women. Recent studies provide preliminary and supportive evidence on safety, immunogenicity and effectiveness of coronavirus disease 2019 (COVID-19) vaccines in pregnant women; however, important knowledge gaps remain which warrant further studies. This collaborative consensus paper provides a review of the current literature on COVID-19 vaccines in pregnant women, identifies knowledge gaps and outlines priorities for future research to optimize protection against SARS-CoV-2 in the pregnant women and their infants.

Keywords: COVID-19; SARS-CoV-2; maternal immunization; maternal vaccination program; pregnant women.

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Conflict of interest statement

SE: Research support from GSK, Sanofi and Vifor. Speaker’s fees from GSK, Pfizer, Novartis, Sanofi Pasteur and MSD in the past three years. BA is supported by Michael Smith Health Research BC. MO’R: Received research funding for Phase III Covid-19 vaccine trial from Janssen; Received research funding for Phase II Pneumococcal conjugate vaccine trial from Pfizer. VD-B: no conflict of interest to declare. SM: Institution received funding on COVID-19 from BMGF, South African Medical Research Council and Novavax. Also, participating in clinical trials of Pfizer/Biontech and JJ Covid-19 vaccines in pregnant women. MS is a member of the data safety and monitoring board for Janssen and CEPI and received research grants and/or consultancy fees from Astra Zeneca, Janssen, Pfizer, Sanofi, Seqirus, Takeda, MSD and GSK. KF is a member of the Australian Technical Advisory Group on Immunisation noting that this paper represents her own personal view; received honoraria as a member of the vaccine advisory boards for Seqiris and Sanofi Pasteur in the last 5 years. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

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Global Perspectives on Immunization Against SARS-CoV-2 During Pregnancy and Priorities for Future Research: An International Consensus Paper From the World Association of Infectious Diseases and Immunological Disorders

Affiliations

Global Perspectives on Immunization Against SARS-CoV-2 During Pregnancy and Priorities for Future Research: An International Consensus Paper From the World Association of Infectious Diseases and Immunological Disorders

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous