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Review
. 2021 Dec 31:2021:9982192.
doi: 10.1155/2021/9982192. eCollection 2021.

Elevated P-Element-Induced Wimpy-Testis-Like Protein 1 Expression Predicts Unfavorable Prognosis for Patients with Various Cancers

Kehua Jiang  1   2 , Tao Ye  3 , Juan Du  1 , Lanlan Tang  1 , Xiaolong Chen  1 , Fa Sun  1 , Xifeng Sun  4
Affiliations
Review

Elevated P-Element-Induced Wimpy-Testis-Like Protein 1 Expression Predicts Unfavorable Prognosis for Patients with Various Cancers

Kehua Jiang et al. J Oncol. .

Abstract

Increasing evidence has shown that overexpression of P-element-induced wimpy-testis (PIWI)-like protein 1 (PIWIL1) was associated with unfavorable prognosis of patients with various types of cancers. Herein, we conducted this meta-analysis to identify the clinicopathological and prognostic value of the PIWIL1 expression in cancers. Three electronic databases (PubMed, Web of Science, and Embase) were comprehensively retrieved for relevant studies up to August 4th, 2019. RevMan 5.3 and STATA 12.0 statistical software programs were used to explore the relationships between PIWIL1 expression and the prognosis and clinicopathological features in cancer patients. A total of 13 studies recruiting 2179 patients with 9 types of solid tumors were finally included in the meta-analysis. The results indicated that patients with high PIWIL1 expression tended to have a shorter survival, and additionally deeper tumor invasion, higher clinical stage, and more lymph node metastasis. PIWIL1 could serve as a biomarker for prognosis and clinicopathological characteristics in various cancers.

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Conflict of interest statement

All authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of literature research and selection process.
Figure 2
Figure 2
Forest plots of the association of PIWIL1 expression with OS, CSS, and DFS/RFS in various cancers.
Figure 3
Figure 3
Forest plots of the association of PIWIL1 expression with(a) age, (b) gender, (c) tumor size, (d) differentiation, and (e) tumor invasion.
Figure 4
Figure 4
Forest plots of the association of PIWIL1 expression with (a) clinical stage, (b) lymph node metastasis (LNM), and (c) distant metastasis (DM).
Figure 5
Figure 5
Sensitivity analysis plot of the association of PIWIL1 expression with OS.
Figure 6
Figure 6
Begg's funnel plots of the association of PIWIL1 expression with OS.
See this image and copyright information in PMC

References

    1. Siegel R. L., Miller K. D., Jemal A. Cancer statistics. CA: A Cancer Journal for Clinicians . 2018;68(1):7–30. doi: 10.3322/caac.21442. - DOI - PubMed
    1. Bray F., Ferlay J., Soerjomataram I., Siegel R. L., Torre L. A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians . 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Lin H., Spradling A. C. A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development . 1997;124(12):2463–2476. doi: 10.1242/dev.124.12.2463. - DOI - PubMed
    1. Cox D. N., Chao A., Lin H. Piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells. Development . 2000;127(3):503–514. doi: 10.1242/dev.127.3.503. - DOI - PubMed
    1. Seipel K., Yanze N., Schmid V. The germ line and somatic stem cell gene Cniwi in the jellyfish Podocoryne carnea. International Journal of Developmental Biology . 2004;48(1):1–7. doi: 10.1387/ijdb.15005568. - DOI - PubMed