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Review
. 2021 Dec 30:2021:8610285.
doi: 10.1155/2021/8610285. eCollection 2021.

Cognitive Impairment in Genetic Parkinson's Disease

A Planas-Ballvé  1 , D Vilas  2
Affiliations
Review

Cognitive Impairment in Genetic Parkinson's Disease

A Planas-Ballvé et al. Parkinsons Dis. .

Abstract

Cognitive impairment is common in idiopathic Parkinson's disease (PD). Knowledge of the contribution of genetics to cognition in PD is increasing in the last decades. Monogenic forms of genetic PD show distinct cognitive profiles and rate of cognitive decline progression. Cognitive impairment is higher in GBA- and SNCA-associated PD, lower in Parkin- and PINK1-PD, and possibly milder in LRRK2-PD. In this review, we summarize data regarding cognitive function on clinical studies, neuroimaging, and biological markers of cognitive decline in autosomal dominant PD linked to mutations in LRRK2 and SNCA, autosomal recessive PD linked to Parkin and PINK1, and also PD linked to GBA mutations.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this study.

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