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Review
. 2021 Dec 23:8:771297.
doi: 10.3389/fmed.2021.771297. eCollection 2021.

The Impact of Trace Elements on Osteoarthritis

Guoyong Li  1 , Tao Cheng  2 , Xuefeng Yu  1
Affiliations
Review

The Impact of Trace Elements on Osteoarthritis

Guoyong Li et al. Front Med (Lausanne). .

Abstract

Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has a multifactorial etiology with potential contributions from heredity, endocrine function, abnormal mechanical load and nutrition. Of particular considerations are trace element status. Several trace elements, such as boron and magnesium are essential for normal development of the bone and joint in human. While cadmium correlates with the severity of OA. The present review focuses on the roles of trace elements (boron, cadmium, copper, iron, magnesium, manganese, selenium, zinc) in OA and explores the mechanisms by which they act.

Keywords: deficiency; excess; osteoarthritis; role; trace elements.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The effects of trace elements on OA. B, boron; Cd, cadmium; Cu, copper; Fe, iron; Mg, magnesium; Mn, manganese; Se, selenium; Zn, zinc. Trace elements such as boron and selenium have anti-inflammatory and antioxidant effects, increasing cartilage matrix formation and enhancing chondrocyte proliferation, resulting in preventing and treating OA. However, excessive or insufficient trace elements like copper are risk factors for osteoarthritis.
See this image and copyright information in PMC

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