Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec 23:8:771297.
doi: 10.3389/fmed.2021.771297. eCollection 2021.

The Impact of Trace Elements on Osteoarthritis

Guoyong Li  1 , Tao Cheng  2 , Xuefeng Yu  1
Affiliations
Review

The Impact of Trace Elements on Osteoarthritis

Guoyong Li et al. Front Med (Lausanne). .

Abstract

Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has a multifactorial etiology with potential contributions from heredity, endocrine function, abnormal mechanical load and nutrition. Of particular considerations are trace element status. Several trace elements, such as boron and magnesium are essential for normal development of the bone and joint in human. While cadmium correlates with the severity of OA. The present review focuses on the roles of trace elements (boron, cadmium, copper, iron, magnesium, manganese, selenium, zinc) in OA and explores the mechanisms by which they act.

Keywords: deficiency; excess; osteoarthritis; role; trace elements.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The effects of trace elements on OA. B, boron; Cd, cadmium; Cu, copper; Fe, iron; Mg, magnesium; Mn, manganese; Se, selenium; Zn, zinc. Trace elements such as boron and selenium have anti-inflammatory and antioxidant effects, increasing cartilage matrix formation and enhancing chondrocyte proliferation, resulting in preventing and treating OA. However, excessive or insufficient trace elements like copper are risk factors for osteoarthritis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Carlson AK, Rawle RA, Wallace CW, Brooks EG, Adams E, Greenwood MC, et al. . Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis. Osteoarthritis Cartilage. (2019) 27:1174–84. 10.1016/j.joca.2019.04.007 - DOI - PMC - PubMed
    1. Kosik-Bogacka DI, Lanocha-Arendarczyk N, Kot K, Ciosek Z, Zietek P, Karaczun M, et al. . Effects of biological factors and health condition on mercury and selenium concentrations in the cartilage, meniscus and anterior cruciate ligament. J Trace Elem Med Biol. (2017) 44:201–8. 10.1016/j.jtemb.2017.08.008 - DOI - PubMed
    1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators . Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (London, England). (2018) 392:1789–858. 10.1016/S0140-6736(18)32279-7 - DOI - PMC - PubMed
    1. Misra D, Fielding RA, Felson DT, Niu J, Brown C, Nevitt M, et al. . Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia. Arthritis Rheumatol (Hoboken, NJ). (2019) 71:232–7. 10.1002/art.40692 - DOI - PMC - PubMed
    1. Al-Mahrouqi MM, Vicenzino B, MacDonald DA, Smith MD. Disability, physical impairments, and poor quality of life, rather than radiographic changes, are related to symptoms in individuals with ankle osteoarthritis: a cross-sectional laboratory study. J Orthop Sports Phys Ther. (2020) 50:711–22. 10.2519/jospt.2020.9376 - DOI - PubMed

LinkOut - more resources