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. 1987 Dec;84(23):8613-7.
doi: 10.1073/pnas.84.23.8613.

Allogeneic H-2 antigen expression is insufficient for tumor rejection

G A Cole  1 , G A Cole, V K Clements, E P Garcia, S Ostrand-Rosenberg
Affiliations

Allogeneic H-2 antigen expression is insufficient for tumor rejection

G A Cole et al. Proc Natl Acad Sci U S A. 1987 Dec.

Abstract

Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection.

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References

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