Will There Ever Be Cure for Chronic, Life-Changing Colistin-Resistant Klebsiella pneumoniae in Urinary Tract Infection?

Aye Mya Sithu Shein^{1

2

3}, Parichart Hongsing^{4

5}, Shuichi Abe⁶, Sirirat Luk-In⁷, Naveen Kumar Devanga Ragupathi^{8

9

10}, Dhammika Leshan Wannigama^{1

2

8

11}, Tanittha Chatsuwan^{1

2}

Affiliations

¹ Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
² Antimicrobial Resistance and Stewardship Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
³ Interdisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand.
⁴ Mae Fah Luang University Hospital, Chiang Rai, Thailand.
⁵ School of Integrative Medicine, Mae Fah Luang University, Chiang Rai, Thailand.
⁶ Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata, Japan.
⁷ Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
⁸ Biofilms and Antimicrobial Resistance Consortium of ODA Receiving Countries, The University of Sheffield, Sheffield, United Kingdom.
⁹ Department of Chemical and Biological Engineering, The University of Sheffield, Sheffield, United Kingdom.
¹⁰ Department of Clinical Microbiology, Christian Medical College, Vellore, India.
¹¹ School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, WA, Australia.

PMID: 35004783
PMCID: PMC8740227
DOI: 10.3389/fmed.2021.806849

Will There Ever Be Cure for Chronic, Life-Changing Colistin-Resistant Klebsiella pneumoniae in Urinary Tract Infection?

Aye Mya Sithu Shein et al. Front Med (Lausanne). 2021.

. 2021 Dec 24:8:806849.

doi: 10.3389/fmed.2021.806849. eCollection 2021.

Authors

Affiliations

¹ Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
² Antimicrobial Resistance and Stewardship Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
³ Interdisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand.
⁴ Mae Fah Luang University Hospital, Chiang Rai, Thailand.
⁵ School of Integrative Medicine, Mae Fah Luang University, Chiang Rai, Thailand.
⁶ Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata, Japan.
⁷ Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
⁸ Biofilms and Antimicrobial Resistance Consortium of ODA Receiving Countries, The University of Sheffield, Sheffield, United Kingdom.
⁹ Department of Chemical and Biological Engineering, The University of Sheffield, Sheffield, United Kingdom.
¹⁰ Department of Clinical Microbiology, Christian Medical College, Vellore, India.
¹¹ School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, WA, Australia.

PMID: 35004783
PMCID: PMC8740227
DOI: 10.3389/fmed.2021.806849

No abstract available

Keywords: Klebsiella pneumoniae; biofilm infections; chronic infection; chronic urinary infection; colistin-resistant; colistin-resistant Klebsiella pneumoniae; urinary tract infection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**Figure 1**
Intrinsic chromosome-mediated and acquired plasmid-mediated colistin resistance mechanisms in *Klebsiella pneumoniae togeetrh* with biofilm formation in chronic, life-changing urinary tract infection.

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Will There Ever Be Cure for Chronic, Life-Changing Colistin-Resistant Klebsiella pneumoniae in Urinary Tract Infection?

Affiliations

Will There Ever Be Cure for Chronic, Life-Changing Colistin-Resistant Klebsiella pneumoniae in Urinary Tract Infection?

Authors

Affiliations

Conflict of interest statement

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