Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 23:8:795599.
doi: 10.3389/fnut.2021.795599. eCollection 2021.

Improving Brain Creatine Uptake by Klotho Protein Stimulation: Can Diet Hit the Big Time?

Sergej M Ostojic  1 , Dagrun Engeset  1
Affiliations

Improving Brain Creatine Uptake by Klotho Protein Stimulation: Can Diet Hit the Big Time?

Sergej M Ostojic et al. Front Nutr. .
No abstract available

Keywords: CT1; Klotho (KL); brain; creatine; curcumin; low-calorie high-protein diet; phosphate-restricted diet; vitamin D2.

PubMed Disclaimer

Conflict of interest statement

SO serves as a member of the Scientific Advisory Board on creatine in health and medicine (AlzChem LLC.). SO owns patent “Sports Supplements Based on Liquid Creatine” at European Patent Office (WO2019150323 A1), and active patent application “Synergistic Creatine” at UK Intellectual Property Office (GB2012773.4). SO has served as a speaker at Abbott Nutrition, a consultant of Allied Beverages Adriatic and IMLEK, and has received research funding related to creatine and/or guanidinoacetic acid from the Serbian Ministry of Education, Science, and Technological Development, Provincial Secretariat for Higher Education and Scientific Research, AlzChem GmbH, KW Pfannenschmidt GmbH, Monster Beverage Corporation, and ThermoLife International LLC. SO does not own stocks and shares in any organization. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Various dietary interventions upregulate Klotho protein expression/activity that further can stimulate (+) creatine uptake via creatine transporter (CT1) in the brain.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Wallimann T, Tokarska-Schlattner M, Schlattner U. The creatine kinase system and pleiotropic effects of creatine. Amino Acids. (2011) 40:1271–96. 10.1007/s00726-011-0877-3 - DOI - PMC - PubMed
    1. Fons C, Campistol J. Creatine defects and central nervous system. Semin Pediatr Neurol. (2016) 23:285–9. 10.1016/j.spen.2016.11.003 - DOI - PubMed
    1. Edmondson DA, Xia P, McNally Keehn R, Dydak U, Keehn B A. magnetic resonance spectroscopy study of superior visual search abilities in children with autism spectrum disorder. Autism Res. (2020) 13:550–62. 10.1002/aur.2258 - DOI - PMC - PubMed
    1. van den Bogaard SJ, Dumas EM, Teeuwisse WM, Kan HE, Webb A, Roos RA, et al. . Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington's disease provides in vivo evidence for impaired energy metabolism. J Neurol. (2011) 258:2230–9. 10.1007/s00415-011-6099-5 - DOI - PMC - PubMed
    1. Lin AQ, Shou JX Li XY, Ma L, Zhu XH. Metabolic changes in acute cerebral infarction: Findings from proton magnetic resonance spectroscopic imaging. Exp Ther Med. (2014) 7:451–5. 10.3892/etm.2013.1418 - DOI - PMC - PubMed

LinkOut - more resources