MPTP Parkinsonism and Implications for Understanding Parkinson's Disease

. 2021 Sep 25;9(1):42-47.

doi: 10.1002/mdc3.13344. eCollection 2022 Jan.

Sohaila AlShimemeri^{1

2

3

4}, Daniel G Di Luca^{1

2

3}, Susan H Fox^{1

2

3}

Affiliations

¹ The Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital Toronto Ontario Canada.
² Krembil Brain Institute, University Health Network Toronto Ontario Canada.
³ Division of Neurology University of Toronto Toronto Ontario Canada.
⁴ King Saud University Riyadh Saudi Arabia.

Sohaila AlShimemeri et al. Mov Disord Clin Pract. 2021.

. 2021 Sep 25;9(1):42-47.

doi: 10.1002/mdc3.13344. eCollection 2022 Jan.

Sohaila AlShimemeri^{1

2

3

4}, Daniel G Di Luca^{1

2

3}, Susan H Fox^{1

2

3}

¹ The Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital Toronto Ontario Canada.
² Krembil Brain Institute, University Health Network Toronto Ontario Canada.
³ Division of Neurology University of Toronto Toronto Ontario Canada.
⁴ King Saud University Riyadh Saudi Arabia.

No abstract available

Keywords: MPTP; model; parkinsonism.

Conflict of interest statement

There were no funding sources for this paper and no conflicts of interest.

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1. Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic parkinsonism in humans due to a product of meperidine‐analog synthesis. Science 1983;219:979–980. - PubMed
1. Ballard PA, Tetrud JW, Langston JW. Permanent human parkinsonism due to 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP): seven cases. Neurology 1985;35:949–956. - PubMed
1. Merello M, Bhatia KP, Obeso JA. SARS‐CoV‐2 and the risk of Parkinson's disease: facts and fantasy. Lancet Neurol 2021;20:94–95. - PMC - PubMed
1. Sacks Oliver. Awakenings. Pan Macmillan; 1991:
1. Di Monte DA, McCormack A, Petzinger G, Janson AM, Quik M, Langston WJ. Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model. Mov Disord 2000;15:459–466. - PubMed