The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology
- PMID: 35005105
- PMCID: PMC8720660
- DOI: 10.1016/j.gendis.2020.07.008
The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology
Abstract
KiSS-1, first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10. These products are endogenous ligands coupled to G protein-coupled receptor 54 (GPR54)/hOT7T175/AXOR12. To date, the regulatory activities of the KiSS-1/GPR54 system, such as puberty initiation, antitumor metastasis, fertility in adulthood, hypothalamic-pituitary-gonadal axis (HPG axis) feedback, and trophoblast invasion, have been investigated intensively. Accumulating evidence has demonstrated that KiSS-1 played a key role in reproduction and served as a promising biomarker relative to the diagnosis, identification of therapeutic targets and prognosis in various carcinomas, while few studies have systematically summarized its subjective factors and concluded the functions of KiSS-1/GPR54 signaling in physiology homeostasis and cancer biology. In this review, we retrospectively summarized the regulators of the KiSS-1/GPR54 system in different animal models and reviewed its functions according to physiological homeostasis regulations and above all, cancer biology, which provided us with a profound understanding of applying the KiSS-1/GPR54 system into medical applications.
Keywords: KiSS-1/GPR54; Kisspeptin; Physiological homeostasis; Regulators in vivo and in vitro; Tumor metastasis.
© 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.
Conflict of interest statement
The authors declare no competing financial interests.
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