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. 1987 Nov 20;238(4830):1144-6.
doi: 10.1126/science.3500512.

Lymphotoxin is an important T cell-derived growth factor for human B cells

J H Kehrl  1 , M Alvarez-Mon, G A Delsing, A S Fauci
Affiliations

Lymphotoxin is an important T cell-derived growth factor for human B cells

J H Kehrl et al. Science. .

Abstract

Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin enhanced the proliferation of activated B cells and augmented B cell proliferation and immunoglobulin secretion induced by interleukin-2.

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