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. 1987 Dec 18;238(4834):1707-9.
doi: 10.1126/science.3500515.

Three-dimensional structure of interleukin-2

B J Brandhuber  1 , T Boone, W C Kenney, D B McKay
Affiliations

Three-dimensional structure of interleukin-2

B J Brandhuber et al. Science. .

Abstract

Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.

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