Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec;7(4):134-139.
doi: 10.1016/j.afos.2021.11.004. Epub 2021 Dec 4.

Comparison of bone mineral density and vertebral fracture assessment in postmenopausal women with and without distal radius fractures

Tanawat Amphansap  1 , Chayaphong Rattanaphonglekha  1 , Jaruwat Vechasilp  1 , Nitirat Stitkitti  1 , Kamonchalat Apiromyanont  2 , Atiporn Therdyothin  1
Affiliations

Comparison of bone mineral density and vertebral fracture assessment in postmenopausal women with and without distal radius fractures

Tanawat Amphansap et al. Osteoporos Sarcopenia. 2021 Dec.

Abstract

Objectives: To compare bone mineral density (BMD) in Thai postmenopausal women with and without distal radius fracture, and to investigate the role of vertebral fracture assessment (VFA) in diagnosing osteoporosis after distal radius fracture.

Methods: A cross-sectional study was conducted in Thai postmenopausal women with and without distal radius fracture. BMDs of the femoral neck (FN), total hip (TH), lumbar spine (LS), and VFA were obtained within 2 weeks of injury. BMD were compared between groups. Participants were classified into osteoporosis, osteopenia or normal using BMD alone, and BMD plus VFA, where a mere presence of vertebral compression fracture indicated osteoporosis.

Results: Fifty postmenopausal women with distal radius fractures and 111 non-fracture postmenopausal women participated. The mean BMD was significantly lower at all sites in the fracture group (FN BMD 0.590 ± 0.075 vs 0.671 ± 0.090, p = 0.007; TH BMD 0.742 ± 0.103 vs 0.828 ± 0.116, P = 0.009; LS BMD 0.799 ± 0.107 vs 0.890 ± 0.111, P = 0.009 in the fracture vs non-fracture group respectively). VFA increased the prevalence of osteoporosis from 16 (32%) to 23 (46%) in the fracture group, and 7 (6.31%) to 17 (16.22%) in the non-fracture group, with a number needed to treat 9.

Conclusions: Postmenopausal women with distal radius fractures had lower BMD. Incorporating VFA into diagnosis of osteoporosis increased the prevalence of osteoporosis in both fracture and non-fracture groups. Postmenopausal women aged 50 years or older with distal radius fracture are a good target for the investigation of osteoporosis.

Keywords: Bone mineral density; Distal radius fracture; Osteoporosis; Vertebral compression fracture; Vertebral fracture assessment.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of site-related bone mineral density in fracture and non-fracture group, LS = lumbar spine, TH = total hip, FN = femoral neck, BMD = bone mineral density.
See this image and copyright information in PMC

References

    1. Sebastin S.J., Chung K.C. An Asian perspective on the management of distal radius fractures. Hand Clin. 2012;28:151–156. - PMC - PubMed
    1. Kanis J.A. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994;4:368–381. - PubMed
    1. Mallmin H., Ljunghall S., Persson I., Naessén T., Krusemo U.B., Bergström R. Fracture of the distal forearm as a forecaster of subsequent hip fracture: a population-based cohort study with 24 years of follow-up. Calcif Tissue Int. 1993;52:269–272. - PubMed
    1. Sornay-Rendu E., Munoz F., Garnero P., Duboeuf F., Delmas P.D. Identification of osteopenic women at high risk of fracture: the OFELY study. J Bone Miner Res. 2005;20:1813–1819. - PubMed
    1. Bozkurt H.H., Atik O., Tokgöz M.A. Can distal radius or vertebra fractures due to low-energy trauma be a harbinger of a hip fracture? Eklem Hastalik Cerrahisi. 2018;29:100–103. - PubMed