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. 2021 Apr:17:1-7.
doi: 10.1016/j.coemr.2020.09.009. Epub 2020 Oct 9.

Sleep and Puberty

Janet N Lucien  1 , Madison T Ortega  1 , Natalie D Shaw  1
Affiliations

Sleep and Puberty

Janet N Lucien et al. Curr Opin Endocr Metab Res. 2021 Apr.

Abstract

In the 1970's, Boyar and colleagues made the seminal observation that during the early stages of puberty, there is a sleep-specific augmentation of pulsatile luteinizing hormone (LH) secretion. Building on this tantalizing association between sleep and the re-awakening of the neuro-reproductive axis, a number of investigators have since mapped the dynamic relationship between sleep and reproductive hormones across the pubertal transition. In this review, we focus on the complex, reciprocal relationship between sleep and reproductive hormones during adolescence as well as the potential effects of melatonin and orexin on gonadotropin-releasing hormone (GnRH) activity in children with chronic insomnia and narcolepsy, respectively. Given the important interaction between the reproductive and somatotropic axes during puberty, we end with a discussion of sleep and growth hormone (GH) secretion in children.

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References

    1. Boyar R, Finkelstein J, Roffwarg H, Kapen S, Weitzman E, Hellman L, Synchronization of augmented luteinizing hormone secretion with sleep during puberty, N.Engl.J Med 287(12) (1972) 582–586. - PubMed
    1. Kapen S, Boyar RM, Finkelstein JW, Hellman L, Weitzman ED, Effect of sleep-wake cycle reversal on luteinizing hormone secretory pattern in puberty, J.Clin.Endocrinol.Metab 39(2) (1974) 293–299. - PubMed

    1. Shaw ND, Butler JP, McKinney SM, Nelson SA, Ellenbogen JM, Hall JE, Insights into puberty: The relationship between sleep stages and pulsatile LH secretion, Journal of Clinical Endocrinology and Metabolism 97(11) (2012).

      * The first study to report a close temporal association between LH pulse onset and deep (slow wave sleep in pubertal children.

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