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Case Reports
. 2021 Nov 2;5(1):58-61.
doi: 10.1002/iju5.12394. eCollection 2022 Jan.

Isolated recurrence of prostate cancer to the anterior urethra 5 years after radiation therapy

Shinnosuke Fujiwara  1 , Masaru Ishida  1 , Eri Arai  2 , Yuto Baba  1 , Tadatsugu Anno  1 , Hiroaki Kobayashi  1 , Yasumasa Miyazaki  1
Affiliations
Case Reports

Isolated recurrence of prostate cancer to the anterior urethra 5 years after radiation therapy

Shinnosuke Fujiwara et al. IJU Case Rep. .

Abstract

Introduction: Primary or metastatic urethral tumors are extremely rare. However, treatment strategies differ between primary and metastatic tumors. Therefore, establishing an accurate diagnosis is critically needed for initiating timely and appropriate therapy.

Case presentation: We describe the case of a 79-year-old man with prostate cancer treated with radiotherapy and androgen deprivation therapy. He presented with macroscopic hematuria as a symptom of anterior urethral tumor at follow-up. Endoscopic tumor resection was performed. Hematoxylin and eosin staining showed adenocarcinoma component. Immunohistochemical staining revealed presence of metastatic prostate cancer to the urethra.

Conclusion: Regarding urethral tumors diagnosis, urologists should consider the possibility of metastasis from prostate cancer and perform immunohistochemical examination for establishing accurate diagnosis. Furthermore, if androgen deprivation therapy fails to suppress symptoms, radiotherapy or urethrectomy might be considered.

Keywords: adenocarcinoma; androgen antagonists; local neoplasms recurrence; prostatic neoplasms; urethra.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Cystoscopy of the anterior urethra. (a) MRI showing the anterior urethral tumor (b, c) (yellow arrows).
Fig. 2
Fig. 2
Biopsy specimen of the urethral tumor. Tumor shows morphology of acinar adenocarcinoma (a) with vascular invasion; (b) immunohistochemistry for CD34 and positive immunohistochemical staining for PSA; (c) and androgen receptors (d).
Fig. 3
Fig. 3
Cystoscopy of the anterior urethra 2 months after resection.
See this image and copyright information in PMC

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