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Review
. 2021 Oct 30:4:100130.
doi: 10.1016/j.jtauto.2021.100130. eCollection 2021.

Regulatory T cell function in autoimmune disease

Anandi Rajendeeran  1 , Klaus Tenbrock  1
Affiliations
Review

Regulatory T cell function in autoimmune disease

Anandi Rajendeeran et al. J Transl Autoimmun. .

Abstract

Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.

Keywords: Foxp3; IL-2; Juvenile idiopathic arthritis; Regulatory T cells; SLE.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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