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. 2022 Feb;27(1):e12866.
doi: 10.1111/hel.12866. Epub 2022 Jan 10.

Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers

Takako Osaki  1 , Yingsong Lin  2 , Naoki Sasahira  3 , Makoto Ueno  4 , Hideo Yonezawa  1 , Fuhito Hojo  5 , Masumi Okuda  6 , Masato Matsuyama  3 , Takashi Sasaki  3 , Satoshi Kobayashi  4 , Shun Tezuka  4 , Kei Tanaka  7 , Naoaki Dan  7 , Sawako Kuruma  8 , Naoto Egawa  9 , Shigeru Kamiya  1 , Shogo Kikuchi  2
Affiliations

Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers

Takako Osaki et al. Helicobacter. 2022 Feb.

Abstract

Background: Helicobacter pylori infection is a well-established risk factor for gastric cancer and has been linked to other gastrointestinal diseases, including pancreatic and biliary tract cancers; however, the relevance of enterohepatic non-H. pylori helicobacters to the pathophysiology of these diseases remains unclear.

Materials and methods: We estimated the prevalence of two enterohepatic non-H. pylori helicobacters (Helicobacter hepaticus and Helicobacter bilis) in the framework of a hospital-based case-control study involving 121 patients with biliary tract cancer, pancreatic cancer, or other gastrointestinal diseases. Bile and blood samples were collected from the patients undergoing endoscopic retrograde cholangiopancreatography. The presence of H. bilis, H. hepaticus, and other Helicobacter spp. was examined using bacterial culture, PCR-based detection, and serological tests.

Results: Culture of Helicobacter spp. from biliary brush samples was unsuccessful. Approximately 13.0% (15/115) of the bile samples collected from patients with a variety of gastrointestinal cancers, including pancreatic and biliary tract cancers, tested positive for one of the enterohepatic non-H. pylori helicobacter species as determined by PCR. Specifically, H. bilis and H. hepaticus DNA were detected in 11 and 4 bile samples, respectively. Approximately 20%-40% of the patients tested positive for serum non-H. pylori helicobacter IgG antibodies. The seroprevalence of H. bilis and H. hepaticus in the patients without evidence of H. pylori infection appeared to be higher in the pancreatic cancer group than in the control group.

Conclusion: Our findings suggest a role for Helicobacter spp., especially H. bilis and H. hepaticus, in the etiology of pancreatic and biliary tract cancers.

Keywords: Helicobacter bilis; Helicobacter hepaticus; Helicobacter pylori; biliary tract cancer; enterohepatic helicobacters; pancreatic cancer.

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Conflict of interest statement

All other authors declare no conflicts of interest.

References

    1. Cancer mortality, 1958‐2019 . Cancer Registry and Statistics. Cancer Information Service, National Cancer Center, Japan (Vital Statistics of Japan)
    1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021. - PubMed
    1. Michaud DS. Role of bacterial infections in pancreatic cancer. Carcinogenesis. 2013;34(10):2193‐2197. - PMC - PubMed
    1. Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterology. 2009;136(6):1863‐1873. - PMC - PubMed
    1. Schoch CL, Ciufo S, Domrachev M, et al. NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database (Oxford). 2020. Jan 1;2020:baaa062 http://www.ncbi.nlm.nih.gov/toxonomy - PMC - PubMed