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Meta-Analysis
. 2022 Mar;38(3):365-375.
doi: 10.1007/s00383-021-05049-z. Epub 2022 Jan 10.

"When to Nuss? patient age as a risk factor for complications of minimally invasive repair of pectus excavatum: a systematic review and meta-analysis"

Arielle C Coughlin  1 , Sofia Ahsanuddin  1 , Dani Inglesby  1 , Conner Fox  1 , Hope Xu  1 , Ilana Margulies  1 , Farah Sayegh  1 , Celine Soudant  2 , Henry S Sacks  3 , Andrew Kaufman  4 , Peter J Taub  5
Affiliations
Meta-Analysis

"When to Nuss? patient age as a risk factor for complications of minimally invasive repair of pectus excavatum: a systematic review and meta-analysis"

Arielle C Coughlin et al. Pediatr Surg Int. 2022 Mar.

Abstract

Purpose: The optimal age for minimally invasive repair of pectus excavatum (MIRPE) is unclear; this study investigates the differences in complication rates among different age groups undergoing repair.

Methods: PubMed and Embase databases were searched from inception to October 2020. To assess age as a risk factor for complications, odds ratios from relevant studies were analyzed using the Mantel-Haenszel method with a random-effects model for younger vs older patients. Specific complication rates were compared between the two cohorts using a chi-squared test.

Results: Of the 4448 studies retrieved, 25 studies stratified complication data by age groups. From these studies, ten studies compared groups at ages < 18 and ≥ 18 and four studies compared ages < 20 and ≥ 20, and one study compared ages < 19 and ≥ 19. These fifteen studies reported on 5978 patients, with 1188 complications, for a complication rate of 19.87%. Older patients were more likely to have complications in a pooled analysis of studies comparing older vs younger patients (OR = 1.66, 95% CI = 1.28-2.14, heterogeneity I2 = 49%). Specifically, older patients were significantly more likely to experience pneumothorax, pleural effusion, wound infection, bar displacement, and reoperations.

Conclusion: Increased age is a risk factor for complications of MIRPE. This supports repair of pectus excavatum prior to late adolescence.

Keywords: Chest wall; MIRPE; Nuss; Pectus excavatum; Plastic surgery; Reconstructive surgery.

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