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Comment
. 2022 Jan;18(1):65-66.
doi: 10.1007/s13181-021-00871-2. Epub 2022 Jan 10.

Should the Dosage Cap Be Used in Patients Greater than 100 kg Receiving N-acetylcysteine for Acetaminophen Toxicity?

Noah Gordon Berland  1 , James Leonard  2 , Diane P Calello  2
Affiliations
Comment

Should the Dosage Cap Be Used in Patients Greater than 100 kg Receiving N-acetylcysteine for Acetaminophen Toxicity?

Noah Gordon Berland et al. J Med Toxicol. 2022 Jan.
No abstract available

Keywords: Acetaminophen; Capped dosing; Hepatotoxicity; NAC; Obesity.

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Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Plot of vials for mixing NAC for given weights, with compounding optimized (solid line) and non-optimized compounding (dashed lines), costs are calculated using a vial cost of $16 as per Baum et al. [1]
See this image and copyright information in PMC

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References

    1. Baum RA, Woolum JA, Bailey AM, Howell MM, Weant KA, Geraghty L, Mohan S, Webb AN, Su MK, Akpunonu P, Amirshahi M. Evaluation of dosing strategies of N-acetylcysteine for acetaminophen toxicity in patients greater than 100 kilograms: should the dosage cap be used? J Med Toxicol. 2021;17:241–249. doi: 10.1007/s13181-021-00822-x/Published. - DOI - PMC - PubMed
    1. ACETADOTE (acetylcysteine) injection (package insert). Nashville, TN; Cumberland Pharmaceuticals Inc; 2019. https://www.acetadote.com/New_Acetadote_Labeling_25OCT2019.pdf. Accessed 30 Oct 2021.
    1. Cumberland Pharmaceuticals Inc. ACETADOTE (acetylcysteine) injection (package insert). U.S. Food and Drug Administration. website: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/21-539_Acetadote.... Revised January 2004
    1. Paloucek FP, Kanter MZ. It’s been a long journey: do we know where we are going? J Med Toxicol. 2021;17:239–240. doi: 10.1007/s13181-021-00843-6. - DOI - PMC - PubMed

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