The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data

Seng Chan You¹, Harlan M Krumholz^{2

3

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Affiliations

¹ Department of Preventive Medicine, Yonsei University, College of Medicine, Seoul, Korea (S.C.Y.).
² Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (H.M.K.).
³ Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (H.M.K.).
⁴ Department of Health Policy and Management, Yale School of Public Health, New Haven, CT (H.M.K.).

Editorial

Seng Chan You et al. Circulation. 2022.

. 2022 Jan 11;145(2):107-109.

doi: 10.1161/CIRCULATIONAHA.121.057931. Epub 2022 Jan 10.

Seng Chan You¹, Harlan M Krumholz^{2

3

4}

¹ Department of Preventive Medicine, Yonsei University, College of Medicine, Seoul, Korea (S.C.Y.).
² Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (H.M.K.).
³ Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (H.M.K.).
⁴ Department of Health Policy and Management, Yale School of Public Health, New Haven, CT (H.M.K.).

No abstract available

Keywords: Editorials; drug-eluting stents; dual anti-platelet therapy; evidence-based medicine; percutaneous coronary intervention.

Comment on

Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study.
Butala NM, Faridi KF, Tamez H, Strom JB, Song Y, Shen C, Secemsky EA, Mauri L, Kereiakes DJ, Curtis JP, Gibson CM, Yeh RW. Butala NM, et al. Circulation. 2022 Jan 11;145(2):97-106. doi: 10.1161/CIRCULATIONAHA.121.056878. Epub 2021 Nov 8. Circulation. 2022. PMID: 34743530 Free PMC article.