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. 1987 Nov 13;148(3):1129-36.
doi: 10.1016/s0006-291x(87)80250-4.

Tissue specificity and developmental expression of rat osteopontin

K Yoon  1 , R Buenaga, G A Rodan
Affiliations

Tissue specificity and developmental expression of rat osteopontin

K Yoon et al. Biochem Biophys Res Commun. .

Abstract

Osteopontin is a 44 kd phosphoprotein abundant in bone matrix. We isolated a partial length cDNA for rat osteopontin and used it to examine its tissue specificity, its expression during bone development and its hormonal regulation. Osteopontin mRNA is most abundant in bone but is also found in considerable amounts in kidney. Osteopontin mRNA is regulated by the osteotropic hormones dexamethasone and 1,25(OH)2D3. Estimates of osteopontin mRNA levels indicate that the osteopontin gene is turned on relatively late in calvarial development.

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