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. 2022 Apr;66(4):173-178.
doi: 10.1111/1348-0421.12962. Epub 2022 Mar 3.

Viral shedding and the durability of immunoglobulin G antibodies to severe acute respiratory syndrome coronavirus 2

Maria Inge Lusida  1 , Emily Gunawan  1 , Ni Luh Ayu Megasari  1 , Laura Navika Yamani  1   2 , Juniastuti  1 , Takako Utsumi  1   3 , Yasuko Mori  3
Affiliations
Free article

Viral shedding and the durability of immunoglobulin G antibodies to severe acute respiratory syndrome coronavirus 2

Maria Inge Lusida et al. Microbiol Immunol. 2022 Apr.
Free article

Abstract

We followed 45 participants in Surabaya, Indonesia, for 10 months and compared their PCR and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) results. As much as 13 out of 45 participants were IgG seropositive at least once while the remaining 32 stayed IgG seronegative throughout the study. Among 13 seropositive participants, 9 were consecutively seropositive at least twice and were eligible for IgG longevity evaluation. The duration of IgG detection varied from 47 to ≥233 days. We observed intermittent re-positive PCR results suggestive of viral shedding in participants with a longer duration of IgG detection.

Keywords: COVID-19; Indonesia; SARS-CoV-2; immunoglobulin G.

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