Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Apr;97(4):E132-E135.
doi: 10.1002/ajh.26459. Epub 2022 Jan 13.

COVID-19 vaccine response in patients with hematologic malignancy: A systematic review and meta-analysis

Affiliations
Meta-Analysis

COVID-19 vaccine response in patients with hematologic malignancy: A systematic review and meta-analysis

Inna Y Gong et al. Am J Hematol. 2022 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Visual depiction of pooled seroresponse (95% confidence intervals shown are error bars) and relative benefit ratios when compared to controls following COVID‐19 vaccination in hematologic malignancy patients. Data are presented by hematologic malignancy subtype on the left and by treatment status and type on the right for both pooled response and relative benefit ratios. CLL, chronic lymphocytic leukemia; CAR‐T, chimeric antigen receptor T cell therapy; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasm; SCT, stem cell transplantation

References

    1. Greenberger LM, Saltzman LA, Senefeld JW, Johnson PW, DeGennaro LJ, Nichols GL. Anti‐spike antibody response to SARS‐CoV‐2 booster vaccination in patients with B cell‐derived hematologic malignancies. Cancer Cell. 2021;39(10):1297‐1299. - PMC - PubMed
    1. Anolik JH, Friedberg JW, Zheng B, et al. B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny. Clin Immunol. 2007;122(2):139‐145. - PubMed
    1. Ehmsen S, Asmussen A, Jeppesen SS, et al. Antibody and T cell immune responses following mRNA COVID‐19 vaccination in patients with cancer. Cancer Cell. 2021;39(8):1034‐1036. - PMC - PubMed
    1. Khoury DS, Cromer D, Reynaldi A, et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS‐CoV‐2 infection. Nat Med. 2021;27(7):1205‐1211. - PubMed
    1. Bergwerk M, Gonen T, Lustig Y, et al. Covid‐19 breakthrough infections in vaccinated health care workers. N Engl J Med. 2021;385(16):1474‐1484. - PMC - PubMed

Substances