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. 1987 Oct;35(6):427-8.

[Pharmacokinetics of propofol as an induction agents in adults]

[Article in French]
A Landais  1 , I D Cockshott, M C Coppens, N Cohn, M D Richard, C Saint-Maurice
Affiliations
  • PMID: 3500758

[Pharmacokinetics of propofol as an induction agents in adults]

[Article in French]
A Landais et al. Cah Anesthesiol. 1987 Oct.

Abstract

The disposition kinetics of Propofol have been determined in 7 patients (3 men, 4 women) receiving 2.5 mg/kg for induction of anaesthesia. Peripheral venous samples were collected up to 12 hours after injection of the drug. Data analysis indicates a 3 compartment model with a terminal half-life of 480 +/- 141 min, clearance of 0.0352 +/- 0.0014 l/min/kg and volume of distribution of 24.2 +/- 6.2 l/kg.

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