Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 22;14(1):34.
doi: 10.3390/cancers14010034.

Prognostic Role of the Removed Vaginal Cuff and Its Correlation with L1CAM in Low-Risk Endometrial Adenocarcinoma

Enrico Vizza  1 , Valentina Bruno  1 , Giuseppe Cutillo  1 , Emanuela Mancini  1 , Isabella Sperduti  2 , Lodovico Patrizi  3 , Camilla Certelli  1 , Ashanti Zampa  1 , Andrea Giannini  4 , Giacomo Corrado  5
Affiliations

Prognostic Role of the Removed Vaginal Cuff and Its Correlation with L1CAM in Low-Risk Endometrial Adenocarcinoma

Enrico Vizza et al. Cancers (Basel). .

Abstract

Objective: The aim of our study was to investigate the role of the excised vaginal cuff length as a prognostic factor in terms of DFS and recurrence rate/site, in low-risk endometrial cancer (EC) patients. Moreover, we correlated the recurrence with the expression of L1CAM.

Material and methods: From March 2001 to November 2016, a retrospective data collection was conducted of women undergoing surgical treatment for low-risk EC according to ESMO-ESGO-ESTRO consensus guidelines. Patients were divided into three groups according to their vaginal cuff length: V0 without vaginal cuff, V1 with a vaginal cuff shorter than 1.5 cm and V2 with a vaginal cuff longer than or equal to 1.5 cm.

Results: 344 patients were included in the study: 100 in the V0 group, 179 in the V1 group and 65 in the V2 group. The total recurrence rate was 6.1%: the number of patients with recurrence was 8 (8%), 10 (5.6%) and 3 (4.6%), in the V0, V1 and V2 group, respectively. No statistically significant difference was found in the recurrence rate among the three groups. Although the DFS was higher in the V2 group, the result was not significant. L1CAM was positive in 71.4% of recurrences and in 82% of the distant recurrences.

Conclusions: The rate of recurrence in patients with EC at low risk of recurrence does not decrease as the length of the vaginal cuff removed increases. Furthermore, the size of the removed vaginal cuff does not affect either the site of recurrence or the likelihood of survival.

Keywords: L1CAM; low-risk endometrial cancer; vaginal cuff.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest are disclosed.

Figures

Figure 1
Figure 1
Recurrence sites in the three different groups: v0, v1, v2.
Figure 2
Figure 2
Ten years DFS in the three different groups: v0, v1, v2.
Figure 3
Figure 3
Recurrence site and L1CAM correlation.
See this image and copyright information in PMC

References

    1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics. CA Cancer J. Clin. 2019;69:7–34. doi: 10.3322/caac.21551. - DOI - PubMed
    1. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int. J. Gynaecol. Obstet. 2009;105:103–104. doi: 10.1016/j.ijgo.2009.02.012. - DOI - PubMed
    1. Colombo N., Creutzberg C., Amant F., Bosse T., González-Martín A., Ledermann J., Marth C., Nout R., Querleu D., Mirza M.R., et al. ESMO-ESGO-ESTRO Endometrial Consensus Conference Working Group. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, treatment and follow-up. Ann. Oncol. 2016;27:16–41. doi: 10.1093/annonc/mdv484. - DOI - PubMed
    1. Signorelli M., Lissoni A.A., Cormio G., Katsaros D., Pellegrino A., Selvaggi L., Ghezzi F., Scambia G., Zola P., Grassi R., et al. Modified Radical Hysterectomy Versus Extrafascial Hysterectomy in the Treatment of Stage I Endometrial Cancer: Results from the ILIADE Randomized Study. Ann. Surg. Oncol. 2009;16:3431–3441. doi: 10.1245/s10434-009-0736-6. - DOI - PubMed
    1. Vizza E., Cutillo G., Bruno V., Sperduti I., Mancini E., Baiocco E., Chiofalo B., Cicchillitti L., Certelli C., Zampa A., et al. Pattern of Recurrence in Patients with Endometrial Cancer: A Retrospective Study. Eur. J. Surg. Oncol. 2020;46:1697–1702. doi: 10.1016/j.ejso.2020.03.203. - DOI - PubMed

LinkOut - more resources