Matrix Effectors and Cancer

Zoi Piperigkou^{1

2}, Nikos K Karamanos^{1

2}

Affiliations

¹ Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.
² Foundation for Research and Technology-Hellas (FORTH)/Institute of Chemical Engineering Sciences (ICE-HT), 265 04 Patras, Greece.

PMID: 35008364
PMCID: PMC8750795
DOI: 10.3390/cancers14010200

Editorial

Matrix Effectors and Cancer

Zoi Piperigkou et al. Cancers (Basel). 2021.

. 2021 Dec 31;14(1):200.

doi: 10.3390/cancers14010200.

Authors

Zoi Piperigkou^{1

2}, Nikos K Karamanos^{1

2}

Affiliations

¹ Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.
² Foundation for Research and Technology-Hellas (FORTH)/Institute of Chemical Engineering Sciences (ICE-HT), 265 04 Patras, Greece.

PMID: 35008364
PMCID: PMC8750795
DOI: 10.3390/cancers14010200

Abstract

Extracellular matrices (ECMs) are highly dynamic three-dimensional structural meshworks composed of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, elastin, (glyco)proteins, and matrix-degrading enzymes, such as proteases and glycosidases [...].

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Conflict of interest statement

The authors declare no conflict of interest.

Cited by

Mechanisms of breast cancer metastasis: the role of extracellular matrix.
Chen R, Zhang R, Ke F, Guo X, Zeng F, Liu Q. Chen R, et al. Mol Cell Biochem. 2025 May;480(5):2771-2796. doi: 10.1007/s11010-024-05175-x. Epub 2024 Dec 9. Mol Cell Biochem. 2025. PMID: 39652293 Review.
Trends in extracellular matrix biology.
Kyriakopoulou K, Piperigkou Z, Tzaferi K, Karamanos NK. Kyriakopoulou K, et al. Mol Biol Rep. 2023 Jan;50(1):853-863. doi: 10.1007/s11033-022-07931-y. Epub 2022 Nov 7. Mol Biol Rep. 2023. PMID: 36342580 Free PMC article. Review.

References

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1. Karamanos N.K., Piperigkou Z., Theocharis A.D., Watanabe H., Franchi M., Baud S., Brezillon S., Gotte M., Passi A., Vigetti D., et al. Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics. Chem. Rev. 2018;118:9152–9232. doi: 10.1021/acs.chemrev.8b00354. - DOI - PubMed
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1. Kyykallio H., Oikari S., Bueno Alvez M., Gallardo Dodd C.J., Capra J., Rilla K. The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells. Cancers. 2020;12:1908. doi: 10.3390/cancers12071908. - DOI - PMC - PubMed
1. Nassar E., Hassan N., El-Ghonaimy E.A., Hassan H., Abdullah M.S., Rottke T.V., Kiesel L., Greve B., Ibrahim S.A., Gotte M. Syndecan-1 promotes angiogenesis in triple-negative breast cancer through the prognostically relevant tissue factor pathway and additional angiogenic routes. Cancers. 2021;13:2318. doi: 10.3390/cancers13102318. - DOI - PMC - PubMed

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Matrix Effectors and Cancer

Affiliations

Matrix Effectors and Cancer

Authors

Affiliations

Abstract

Conflict of interest statement

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