Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Dec 31;14(1):200.
doi: 10.3390/cancers14010200.

Matrix Effectors and Cancer

Zoi Piperigkou  1   2 , Nikos K Karamanos  1   2
Affiliations
Editorial

Matrix Effectors and Cancer

Zoi Piperigkou et al. Cancers (Basel). .

Abstract

Extracellular matrices (ECMs) are highly dynamic three-dimensional structural meshworks composed of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, elastin, (glyco)proteins, and matrix-degrading enzymes, such as proteases and glycosidases [...].

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Karamanos N.K., Theocharis A.D., Piperigkou Z., Manou D., Passi A., Skandalis S.S., Vynios D.H., Orian-Rousseau V., Ricard-Blum S., Schmelzer C.E.H., et al. A guide to the composition and functions of the extracellular matrix. FEBS J. 2021;288:6850–6912. doi: 10.1111/febs.15776. - DOI - PubMed
    1. Karamanos N.K., Piperigkou Z., Theocharis A.D., Watanabe H., Franchi M., Baud S., Brezillon S., Gotte M., Passi A., Vigetti D., et al. Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics. Chem. Rev. 2018;118:9152–9232. doi: 10.1021/acs.chemrev.8b00354. - DOI - PubMed
    1. Silva C.F.S., Motta J.M., Teixeira F., Gomes A.M., Vilanova E., Kozlowski E.O., Borsig L., Pavao M.S.G. Non-anticoagulant heparan sulfate from the ascidian phallusia nigra prevents colon carcinoma metastasis in mice by disrupting platelet-tumor cell interaction. Cancers. 2020;12:1353. doi: 10.3390/cancers12061353. - DOI - PMC - PubMed
    1. Kyykallio H., Oikari S., Bueno Alvez M., Gallardo Dodd C.J., Capra J., Rilla K. The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells. Cancers. 2020;12:1908. doi: 10.3390/cancers12071908. - DOI - PMC - PubMed
    1. Nassar E., Hassan N., El-Ghonaimy E.A., Hassan H., Abdullah M.S., Rottke T.V., Kiesel L., Greve B., Ibrahim S.A., Gotte M. Syndecan-1 promotes angiogenesis in triple-negative breast cancer through the prognostically relevant tissue factor pathway and additional angiogenic routes. Cancers. 2021;13:2318. doi: 10.3390/cancers13102318. - DOI - PMC - PubMed

Publication types

LinkOut - more resources