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Review
. 2021 Dec 30;23(1):415.
doi: 10.3390/ijms23010415.

A Review on the Role of miR-149-5p in the Carcinogenesis

Soudeh Ghafouri-Fard  1 , Tayyebeh Khoshbakht  2 , Bashdar Mahmud Hussen  3 , Sepideh Kadkhoda  4 , Mohammad Taheri  5 , Arash Tafrishinejad  6
Affiliations
Review

A Review on the Role of miR-149-5p in the Carcinogenesis

Soudeh Ghafouri-Fard et al. Int J Mol Sci. .

Abstract

miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the "guide" and the sister "passenger" strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.

Keywords: biomarker; cancer; expression; miR-149-5p; ncRNAs.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Tumor-suppressive role of miR-149-5p in esophageal cancer, bladder cancer, breast cancer, ovarian cancer, thyroid cancer and colorectal cancer.
Figure 2
Figure 2
Tumor-suppressive role of miR-149-5p in gastric cancer, lung cancer, colorectal cancer, hepatocellular carcinoma and oral squamous cell carcinoma.
Figure 3
Figure 3
An interaction network between miR-149-5p and long non-coding RNAs (lncRNAs). The pink octagon and green ellipse indicate lncRNAs and miR-149-5p, respectively. The graph visualization was constructed by Cytoscape version 3.6.1.
See this image and copyright information in PMC

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