The Endometrial Microbiome and Its Impact on Human Conception

doi:10.3390/ijms23010485

Review

. 2022 Jan 1;23(1):485.

doi: 10.3390/ijms23010485.

The Endometrial Microbiome and Its Impact on Human Conception

Bruno Toson¹, Carlos Simon^{2

3

4

5}, Inmaculada Moreno²

Affiliations

¹ INCLIVA Biomedical Research Institute, Av. Menendez y Pelayo 4, 46010 Valencia, Spain.
² Igenomix Foundation/INCLIVA Biomedical Research Institute, Narcis Monturiol Estarriol 11B, 46980 Paterna, Spain.
³ Department of Obstetrics and Gynecology, University of Valencia, Av. Blásco Ibáñez 15, 46010 Valencia, Spain.
⁴ Beth Israel Deaconess Medical Center, Harvard University, 330 Brookline Ave, Boston, MA 02215, USA.
⁵ Department of Obstetrics and Gynecology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

PMID: 35008911
PMCID: PMC8745284
DOI: 10.3390/ijms23010485

Review

The Endometrial Microbiome and Its Impact on Human Conception

Bruno Toson et al. Int J Mol Sci. 2022.

. 2022 Jan 1;23(1):485.

doi: 10.3390/ijms23010485.

Authors

Bruno Toson¹, Carlos Simon^{2

3

4

5}, Inmaculada Moreno²

Affiliations

¹ INCLIVA Biomedical Research Institute, Av. Menendez y Pelayo 4, 46010 Valencia, Spain.
² Igenomix Foundation/INCLIVA Biomedical Research Institute, Narcis Monturiol Estarriol 11B, 46980 Paterna, Spain.
³ Department of Obstetrics and Gynecology, University of Valencia, Av. Blásco Ibáñez 15, 46010 Valencia, Spain.
⁴ Beth Israel Deaconess Medical Center, Harvard University, 330 Brookline Ave, Boston, MA 02215, USA.
⁵ Department of Obstetrics and Gynecology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

PMID: 35008911
PMCID: PMC8745284
DOI: 10.3390/ijms23010485

Abstract

Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.

Keywords: assisted reproductive technologies; endometrial microbiota; human reproduction; infertility; microbiome; reproductive outcomes; reproductive tract microbiota; uterus.

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Conflict of interest statement

I.M. and C.S. are partially employed by Igenomix R&D. B.T. declares no conflict of interest.

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References

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1. Perez-Muñoz M.E., Arrieta M.-C., Ramer-Tait A.E., Walter J. A Critical Assessment of the “Sterile Womb” and “in Utero Colonization” Hypotheses: Implications for Research on the Pioneer Infant Microbiome. Microbiome. 2017;5:48. doi: 10.1186/s40168-017-0268-4. - DOI - PMC - PubMed
1. Benner M., Ferwerda G., Joosten I., van der Molen R.G. How Uterine Microbiota Might Be Responsible for a Receptive, Fertile Endometrium. Hum. Reprod. Update. 2018;24:393–415. doi: 10.1093/humupd/dmy012. - DOI - PubMed

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[1] Lederberg J., McCray A.T. ‘Ome Sweet’ Omics—A Genealogical Treasury of Words. [(accessed on 30 November 2021)]; Available online: https://lhncbc.nlm.nih.gov/LHC-publications/pubs/OmeSweetOmicsAGenealogi....

[2] Lederberg J., McCray A.T. ‘Ome Sweet’ Omics—A Genealogical Treasury of Words. [(accessed on 30 November 2021)]; Available online: https://lhncbc.nlm.nih.gov/LHC-publications/pubs/OmeSweetOmicsAGenealogi....

[3] Peterson J., Garges S., Giovanni M., McInnes P., Wang L., Schloss J.A., Bonazzi V., McEwen J.E., Wetterstrand K.A., Deal C., et al. The NIH Human Microbiome Project. Genome Res. 2009;19:2317–2323. doi: 10.1101/gr.096651.109. - DOI - PMC - PubMed

[4] Peterson J., Garges S., Giovanni M., McInnes P., Wang L., Schloss J.A., Bonazzi V., McEwen J.E., Wetterstrand K.A., Deal C., et al. The NIH Human Microbiome Project. Genome Res. 2009;19:2317–2323. doi: 10.1101/gr.096651.109. - DOI - PMC - PubMed

[5] Baker J.M., Chase D.M., Herbst-Kralovetz M.M. Uterine Microbiota: Residents, Tourists, or Invaders? Front. Immunol. 2018;9:208. doi: 10.3389/fimmu.2018.00208. - DOI - PMC - PubMed

[6] Baker J.M., Chase D.M., Herbst-Kralovetz M.M. Uterine Microbiota: Residents, Tourists, or Invaders? Front. Immunol. 2018;9:208. doi: 10.3389/fimmu.2018.00208. - DOI - PMC - PubMed

[7] Perez-Muñoz M.E., Arrieta M.-C., Ramer-Tait A.E., Walter J. A Critical Assessment of the “Sterile Womb” and “in Utero Colonization” Hypotheses: Implications for Research on the Pioneer Infant Microbiome. Microbiome. 2017;5:48. doi: 10.1186/s40168-017-0268-4. - DOI - PMC - PubMed

[8] Perez-Muñoz M.E., Arrieta M.-C., Ramer-Tait A.E., Walter J. A Critical Assessment of the “Sterile Womb” and “in Utero Colonization” Hypotheses: Implications for Research on the Pioneer Infant Microbiome. Microbiome. 2017;5:48. doi: 10.1186/s40168-017-0268-4. - DOI - PMC - PubMed

[9] Benner M., Ferwerda G., Joosten I., van der Molen R.G. How Uterine Microbiota Might Be Responsible for a Receptive, Fertile Endometrium. Hum. Reprod. Update. 2018;24:393–415. doi: 10.1093/humupd/dmy012. - DOI - PubMed

[10] Benner M., Ferwerda G., Joosten I., van der Molen R.G. How Uterine Microbiota Might Be Responsible for a Receptive, Fertile Endometrium. Hum. Reprod. Update. 2018;24:393–415. doi: 10.1093/humupd/dmy012. - DOI - PubMed

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The Endometrial Microbiome and Its Impact on Human Conception

Affiliations

The Endometrial Microbiome and Its Impact on Human Conception

Authors

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Abstract

Conflict of interest statement

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Abstract

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