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Randomized Controlled Trial
. 2021 Dec 27;14(1):108.
doi: 10.3390/nu14010108.

Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia

Antonella Riva  1 , Giovanna Petrangolini  1 , Pietro Allegrini  1 , Simone Perna  2 , Attilio Giacosa  3 , Gabriella Peroni  4 , Milena Anna Faliva  4 , Maurizio Naso  4 , Mariangela Rondanelli  5   6
Affiliations
Randomized Controlled Trial

Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia

Antonella Riva et al. Nutrients. .

Abstract

Botanicals are natural alternatives to pharmacological therapies that aim at reducing hypercholesterolemia. In this context, despite bergamot being effective in modulating lipid profile, some subjects failed to achieve a satisfactory response to supplementation. The aim of this study was to evaluate whether the association of 600 mg of bergamot phytosome® (from Citrus Bergamia Risso) and 100 mg of artichoke leaf standardized dry extract (from Cynara cardunculus L.) can be an alternative in patients with mild hypercholesterolemia who are poor responders to bergamot in a 2-month randomized placebo-controlled trial. Sixty overweight adults were randomized into two groups: 30 were supplemented and 30 received a placebo. The metabolic parameters and DXA body composition were evaluated at the start, after 30 and 60 days. Between the two groups, total and LDL cholesterol in the supplemented group (compared to placebo) showed significant decreases overtime. A significant reduction of waist circumference and visceral adipose tissue (VAT) was recorded in the supplemented group (compared to placebo), even in subjects who did not follow a low-calorie diet. In conclusion, the synergism between Citrus Bergamia polyphenols and Cynara cardunculus extracts may be an effective option and may potentially broaden the therapeutic role of botanicals in dyslipidemic patients.

Keywords: artichoke; bergamot; body composition; mild hypercholesterolemia; phytosome®; poor responders.

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Conflict of interest statement

A.R., G.P. (Giovanna Petrangolini) and P.A. are employees of Indena. S.P., A.G., G.P. (Gabriella Peroni), M.F., M.N. and M.R. declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study.
Figure 2
Figure 2
Pre-post body composition measurements in placebo and intervention groups (within and between effects). *: effects for time.
See this image and copyright information in PMC

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