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. 2022 Jan 5;11(1):268.
doi: 10.3390/jcm11010268.

Swept Source Optical Coherence Tomography Analysis of a Selected Eye's Anterior Segment Parameters in Patients with Pseudoexfoliation Syndrome

Michał Dembski  1   2 , Anna Nowińska  1   2 , Klaudia Ulfik-Dembska  1   2 , Edward Wylęgała  1   2
Affiliations

Swept Source Optical Coherence Tomography Analysis of a Selected Eye's Anterior Segment Parameters in Patients with Pseudoexfoliation Syndrome

Michał Dembski et al. J Clin Med. .

Abstract

Background: Pseudoexfoliation syndrome (PEX) is a systemic, age-related disorder characterized by the production and accumulation of pseudoexfoliation material. To date, detailed characteristics have not been published regarding the iridocorneal angle and cornea in patients with pseudoexfoliation syndrome determined through swept source optical coherence tomography (SS-OCT).

Methods: A total of 150 eyes of patients with pseudoexfoliation syndrome (ages 69-86 years) and 166 eyes in a control group (ages 54-79 years) were analyzed.

Results: The central corneal thickness in the PEX group was 549.56 μm and was slightly (insignificantly) higher than that of the control group (540.56 µm). The anterior chamber of the eye was visibly shallower in patients with PEX syndrome than in those of the control group (2.49 mm vs. 3.07 mm; p < 0.001). The Fourier analysis parameters of the cornea showed multiple differences between the PEX and control groups. With respect to iris area, the parameters showed statistically significant differences between the PEX and control groups in all four quadrants of the eye. No statistical significance was found in the PEX group for the iridocorneal angle parameters, or corneal and lens parameters depending on gender and age.

Conclusions: PEX syndrome is characterized by a significant impact on the anterior eye segment, including higher anterior and posterior keratometric values, lower anterior chamber depth, higher iris thickness, and narrower angle parameters. The characteristic anterior eye segment features of PEX syndrome can be detected using SS-OCT, which could potentially assist clinicians in properly managing the disease.

Keywords: anterior chamber angle; cornea; keratometry; open-angle glaucoma; optical coherence tomography; pseudoexfoliation syndrome.

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Conflict of interest statement

The authors declare that there is no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Comparison of the results of the angle recess area (ARA 250, 500, and 750) in the PEX group and the control group.
Figure 2
Figure 2
Comparison of the results of the trabecular iris space area (TISA 250, 500, and 750) in the PEX group and the control group.
Figure 3
Figure 3
Comparison of the results of the angle opening distance (AOD 250, 500, and 750) in the PEX group and the control group.
Figure 4
Figure 4
Comparison of the results of the trabecular iris angle (TIA 250, 500, and 750) in the PEX group and the control group.
Figure 5
Figure 5
Comparison of the results of the angle parameters based on age.
See this image and copyright information in PMC

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