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. 2021 Dec 23;14(1):37.
doi: 10.3390/polym14010037.

Release of Bisphenol A from Pit and Fissure Sealants According to Different pH Conditions

Eun-Deok Jo  1 , Sang-Bae Lee  1 , Chung-Min Kang  2 , Kwang-Mahn Kim  1 , Jae-Sung Kwon  1   3
Affiliations

Release of Bisphenol A from Pit and Fissure Sealants According to Different pH Conditions

Eun-Deok Jo et al. Polymers (Basel). .

Abstract

Changes in intraoral pH can cause changes in the chemical decomposition and surface properties of treated resin-based pits and fissure sealants (sealant). The purpose of this study is to evaluate the release of bisphenol A (BPA) from sealants under three different pH conditions over time. The test specimen was applied with 6 sealants 5 mg each on a glass plate (10 × 10 mm) and photopolymerized. The samples were immersed for 10 min, 1 h, and 24 h in solutions of pH 3.0, 6.5, and 10.0 at 37 °C. BPA release was measured using a gas chromatography-mass spectrometer. A statistical analysis was performed by two-way ANOVA and one-way ANOVA to verify the effect of pH conditions and time on BPA release. The BPA concentration in the pH 3.0 group was higher at all points than with pH 6.5 and pH 10.0 (p < 0.05), and gradually increased over time (p < 0.05). As a result, it was confirmed that low pH negatively influences BPA release. Therefore, frequent exposure to low pH due to the consumption of various beverages after sealant treatment can negatively affect the sealant's chemical stability in the oral cavity.

Keywords: bisphenol A; dental biomaterials; pH; pit and fissure sealant.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Calibration after GC-MS measurement of the standard samples: (a) Linear calibration of 4 samples, (b) Selected Ion (213.3) bisphenol A 10 ppm, (c) Selected Ion (213.3) bisphenol A 20 ppm, (d) Selected Ion (213.3) bisphenol A 50 ppm, (e) Selected Ion (213.3) bisphenol A 100 ppm.
Figure 2
Figure 2
Differences in BPA concentration (ppm) according to each factor: (a) BPA release according to pH levels (* p < 0.05); (b) BPA release according to time (* p < 0.05).
Figure 3
Figure 3
Comparison of BPA concentration (ppm) according to pH levels (p < 0.05) and time (p < 0.05) of each sealant (A: ClinproTM, B: Eco-s®, C: UltraSeal XT® plus, D: Charmseal®, E: Seal-it®, F: FORTIFY®).
Figure 4
Figure 4
Hydrolysis of resin component: (a) the hydrolysis step of bis-GMA [29]; (b) the types of decomposition products.
See this image and copyright information in PMC

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